Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Feb 2007
Increased risk in patients with high platelet aggregation receiving chronic clopidogrel therapy undergoing percutaneous coronary intervention: is the current antiplatelet therapy adequate?
We sought to determine whether patients receiving chronic clopidogrel therapy undergoing nonemergent stenting who display high on-treatment preprocedural platelet aggregation measured by standard light transmittance aggregometry and thrombelastography (TEG) will be at increased risk for poststenting ischemic events. ⋯ Patients receiving chronic clopidogrel therapy undergoing nonemergent percutaneous coronary intervention who exhibit high on-treatment ADP-induced platelet aggregation are at increased risk for postprocedural ischemic events. These findings might have implications for the alteration in clopidogrel maintenance dose and use of glycoprotein IIb/IIIa inhibitors in selected patients.
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J. Am. Coll. Cardiol. · Feb 2007
Obstructive sleep apnea, obesity, and the risk of incident atrial fibrillation.
This study sought to identify whether obesity and obstructive sleep apnea (OSA) independently predict incident atrial fibrillation/flutter (AF). ⋯ Obesity and the magnitude of nocturnal oxygen desaturation, which is an important pathophysiological consequence of OSA, are independent risk factors for incident AF in individuals <65 years of age.
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J. Am. Coll. Cardiol. · Feb 2007
Total liquid ventilation provides ultra-fast cardioprotective cooling.
We tested whether total liquid ventilation (TLV) can be used to rapidly cool and protect the infarcting heart. ⋯ Total liquid ventilation can elicit rapid cardioprotective cooling during ischemia.