Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Sep 2010
Review Meta AnalysisEvidence of pre-procedural statin therapy a meta-analysis of randomized trials.
The purpose of this study was to summarize the evidence of pre-procedural statin therapy to reduce periprocedure cardiovascular events. ⋯ Statins administered before invasive procedures significantly reduce the hazard of post-procedural MI. Additionally, statins reduce the risk of atrial fibrillation after CABG. The routine use of statins before invasive procedures should be considered.
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Over the past century, multiple studies lacking the precision of today's advanced technology provided conflicting data on the effects of oxygen therapy in normoxic cardiac patients. More importantly, no randomized, blinded, controlled studies have shown a benefit of such treatment. Yet the use of supplemental oxygen is widespread in cardiac patients. ⋯ In recent years, there has been mounting evidence demonstrating the potential adverse effects of hyperoxia on the cardiovascular system. In this report, we review data examining the effects of supplemental oxygen in normoxic patients with acute presentations of coronary artery disease. It is also the aim of this report to emphasize the point that oxygen therapy might have major adverse physiologic effects that must be considered when it is employed.
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J. Am. Coll. Cardiol. · Sep 2010
Clinical TrialMidregional pro-atrial natriuretic peptide and outcome in patients with acute ischemic stroke.
The purpose of this study was to examine the prognostic value of midregional pro-atrial natriuretic peptide (MR-proANP) in patients with acute ischemic stroke. ⋯ MR-proANP is a prognostic marker in the acute phase of stroke, improving the discriminatory value of the NIHSS, independently predicting post-stroke mortality and functional outcome. (The "COSMOS"-Study [Copeptin in Osmoregulation and Stress Assessment]; NCT00390962).
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J. Am. Coll. Cardiol. · Sep 2010
Comparative Study Clinical TrialImpact of systolic and diastolic deformation indexes assessed by strain-encoded imaging to predict persistent severe myocardial dysfunction in patients after acute myocardial infarction at follow-up.
This study evaluated the value of systolic and diastolic deformation indexes determined by strain-encoded imaging to predict persistent severe dysfunction at follow-up in patients after reperfused acute myocardial infarction (AMI) in comparison with late gadolinium enhancement (LGE). ⋯ Regional diastolic function provides similar accuracy to predict persistent severe dysfunction at follow-up to LGE and is superior to regional systolic function in patients after AMI. Diastolic deformation indexes may serve as a new parameter for assessment of viability in patients after AMI. (SENC in AMI Study; NCT00752713).