Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Aug 2013
Comparative StudyPost-mortem cardiac 3-T magnetic resonance imaging: visualization of sudden cardiac death?
This study aimed to investigate post-mortem magnetic resonance imaging (pmMRI) for the assessment of myocardial infarction and hypointensities on post-mortem T2-weighted images as a possible method for visualizing the myocardial origin of arrhythmic sudden cardiac death. ⋯ 3-T pmMRI visualizes chronic, subacute, and acute myocardial infarction in situ. In peracute infarction as a possible cause of sudden cardiac death, it demonstrates affected myocardial areas not visible on autopsy. pmMRI should be considered as a feasible post-mortem investigation technique for the deceased patient if no consent for a clinical autopsy is obtained.
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J. Am. Coll. Cardiol. · Aug 2013
Randomized Controlled Trial Multicenter Study Comparative StudyPrasugrel 5 mg in the very elderly attenuates platelet inhibition but maintains noninferiority to prasugrel 10 mg in nonelderly patients: the GENERATIONS trial, a pharmacodynamic and pharmacokinetic study in stable coronary artery disease patients.
This study assessed pharmacodynamic (PD) response to the reduced prasugrel maintenance dose of 5 mg in very elderly (VE) patients (≥75 years of age). ⋯ In aspirin-treated stable CAD patients, prasugrel 5 mg in VE attenuated platelet inhibition while meeting pre-specified noninferiority criterion versus prasugrel 10 mg in NE, with significantly better PD response and fewer poor responders compared to clopidogrel 75 mg in VE. (Comparison of Prasugrel and Clopidogrel in Very Elderly and Non-Elderly Patients With Stable Coronary Artery Disease [GENERATIONS]; NCT01107912).
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J. Am. Coll. Cardiol. · Aug 2013
Comparative StudyRisk-standardizing survival for in-hospital cardiac arrest to facilitate hospital comparisons.
The purpose of this study is to develop a method for risk-standardizing hospital survival after cardiac arrest. ⋯ We have derived and validated a model to risk-standardize hospital rates of survival for in-hospital cardiac arrest. Use of this model can support efforts to compare hospitals in resuscitation outcomes as a foundation for quality assessment and improvement.
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J. Am. Coll. Cardiol. · Aug 2013
Comparative StudyCoronary microvascular dysfunction and diastolic load correlate with cardiac troponin T release measured by a highly sensitive assay in patients with nonischemic heart failure.
This study investigated factors associated with cardiac troponin T (cTnT) release from failing myocardium. ⋯ cTnT release from failing myocardium correlated with diastolic load and coronary microvascular dysfunction in nonischemic HF patients.
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J. Am. Coll. Cardiol. · Aug 2013
Editorial CommentCrime scene investigation approach to sudden cardiac death.