Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Nov 2014
Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis.
Altered intestinal function is prevalent in patients with heart failure (HF), but its role in adverse outcomes is unclear. ⋯ High TMAO levels were observed in patients with HF, and elevated TMAO levels portended higher long-term mortality risk independent of traditional risk factors and cardiorenal indexes.
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J. Am. Coll. Cardiol. · Nov 2014
Clinical impact of atrial fibrillation in patients with the HeartMate II left ventricular assist device.
Atrial fibrillation (AF) is common in patients with the HeartMate II (HMII) left ventricular assist device (LVAD), but the impact of AF on clinical outcomes is uncertain. ⋯ Although PAF is not associated with worse outcomes in patients with the HMII LVAD, PeAF may be associated with increased mortality and HF hospitalization. Patients with AF also may have thromboembolic events at higher INR levels.