Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Feb 2014
Review Meta AnalysisAortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects.
The goal of this study was to determine whether aortic pulse wave velocity (aPWV) improves prediction of cardiovascular disease (CVD) events beyond conventional risk factors. ⋯ Consideration of aPWV improves model fit and reclassifies risk for future CVD events in models that include standard risk factors. aPWV may enable better identification of high-risk populations that might benefit from more aggressive CVD risk factor management.
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J. Am. Coll. Cardiol. · Feb 2014
Randomized Controlled Trial Comparative StudyImpact of intraprocedural stent thrombosis during percutaneous coronary intervention: insights from the CHAMPION PHOENIX Trial (Clinical Trial Comparing Cangrelor to Clopidogrel Standard of Care Therapy in Subjects Who Require Percutaneous Coronary Intervention).
This study sought to evaluate the clinical impact of intraprocedural stent thrombosis (IPST), a relatively new endpoint. ⋯ In the large-scale CHAMPION PHOENIX trial, the occurrence of IPST was strongly predictive of subsequent adverse cardiovascular events. The potent intravenous adenosine diphosphate antagonist cangrelor substantially reduced IPST, contributing to its beneficial effects at 48 h and 30 days. (Clinical Trial Comparing Cangrelor to Clopidogrel Standard of Care Therapy in Subjects Who Require Percutaneous Coronary Intervention [PCI] [CHAMPION PHOENIX]; NCT01156571).
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J. Am. Coll. Cardiol. · Feb 2014
ReviewPercutaneous interventional therapies for the treatment of patients with severe pulmonary hypertension.
Despite improvements in medical therapy, the overall prognosis of patients with severe pulmonary arterial hypertension remains poor. Heart-lung transplantation or bilateral lung transplantation is the final pathway for a minority. This paper describes both established and novel percutaneous interventional techniques that may palliate or bridge pulmonary hypertension patients to transplantation.
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J. Am. Coll. Cardiol. · Feb 2014
Case Reports Comparative StudyX-shaped secundum atrial septal defect seen by 3-dimensional echocardiography: comparison with open-heart view.