Journal of the American College of Cardiology
-
J. Am. Coll. Cardiol. · Sep 2014
ReviewLaboratory measurement of the anticoagulant activity of the non-vitamin K oral anticoagulants.
Non-vitamin K oral anticoagulants (NOACs) do not require routine laboratory monitoring. However, laboratory measurement may be desirable in special situations and populations. ⋯ Dabigatran, rivaroxaban, and apixaban exhibit variable effects on coagulation assays. Understanding these effects facilitates interpretation of test results in NOAC-treated patients. More information on the relationship between drug levels and clinical outcomes is needed.
-
J. Am. Coll. Cardiol. · Sep 2014
Randomized Controlled TrialImpact of renal denervation on 24-hour ambulatory blood pressure: results from SYMPLICITY HTN-3.
Prior studies of catheter-based renal artery denervation have not systematically performed ambulatory blood pressure monitoring (ABPM) to assess the efficacy of the procedure. ⋯ This trial did not demonstrate a benefit of renal artery denervation on reduction in ambulatory BP in either the 24-h or day and night periods compared with sham (Renal Denervation in Patients With Uncontrolled Hypertension [SYMPLICITY HTN-3]; NCT01418261).
-
J. Am. Coll. Cardiol. · Sep 2014
Editorial CommentRenal denervation for resistant hypertension: not dead yet.