Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Sep 2013
Randomized Controlled Trial Multicenter StudyIntensification of statin therapy results in a rapid reduction in atherosclerotic inflammation: results of a multicenter fluorodeoxyglucose-positron emission tomography/computed tomography feasibility study.
The study sought to test whether high-dose statin treatment would result in greater reductions in plaque inflammation than low-dose statins, using fluorodeoxyglucose-positron emission tomography/computed tomographic imaging (FDG-PET/CT). ⋯ Statin therapy produced significant rapid dose-dependent reductions in FDG uptake that may represent changes in atherosclerotic plaque inflammation. FDG-PET imaging may be useful in detecting early treatment effects in patients at risk or with established atherosclerosis.
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J. Am. Coll. Cardiol. · Sep 2013
Letter Multicenter Study Comparative Study Controlled Clinical TrialDouble versus standard loading dose of ticagrelor: onset of antiplatelet action in patients with STEMI undergoing primary PCI.
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J. Am. Coll. Cardiol. · Sep 2013
Prognostic value of chronic kidney disease after transcatheter aortic valve implantation.
This study sought to assess the influence of chronic kidney disease (CKD) classification on clinical outcomes in patients undergoing transcatheter aortic valve implantation (TAVI). ⋯ Classification of CKD stages before TAVI allows risk stratification for early and midterm clinical outcomes. TAVI for patients with CKD stage 4 is still considered challenging because of high mortality rates after the procedure.
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J. Am. Coll. Cardiol. · Aug 2013
Paradoxical response to exercise in asymptomatic hypertrophic cardiomyopathy: a new description of outflow tract obstruction dynamics.
The purpose of this study was to analyze left ventricular obstruction in patients with hypertrophic cardiomyopathy (HCM) during exercise echocardiography. ⋯ Our study reports a subgroup of HCM patients, designated PRE based on a decreased intraventricular gradient during exercise. The reduced exertional obstruction may account for the better functional class and trend toward fewer clinical events in PRE patients.