Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Mar 2010
Clinical TrialEffect of cyclosporine on left ventricular remodeling after reperfused myocardial infarction.
This study examined the effect of a single dose of cyclosporine administered at the time of reperfusion on left ventricular (LV) remodeling and function by cardiac magnetic resonance 5 days and 6 months after myocardial infarction. ⋯ Cyclosporine used at the moment of acute myocardial infarction reperfusion persistently reduces infarct size and does not have a detrimental effect on LV remodeling. These results are preliminary and must be supported by further studies. (Ciclosporin A and Acute Myocardial Infarction; NCT00403728).
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J. Am. Coll. Cardiol. · Mar 2010
Comparative StudyReport of a National Heart, Lung, And Blood Institute Workshop: heterogeneity in cardiometabolic risk in Asian Americans In the U.S. Opportunities for research.
The Asian and Pacific Islander population (Asian Americans) in the U. S. has increased dramatically in the last few decades. Yet, data on cardiovascular disease (CVD) in this population are scarce. ⋯ S. lifestyles affects health and CVD risk among relatively homogenous groups of recent immigrants. Given the heterogeneity in body weight, body size, and CVD risk, the Asian-American population in the U. S. offers a unique model to study the interaction and relationships between visceral adiposity and adipose tissue distribution and beta cell function, insulin resistance, and atherosclerosis.
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J. Am. Coll. Cardiol. · Feb 2010
The ROSE (risk stratification of syncope in the emergency department) study.
The aim of this study was to develop and validate a clinical decision rule (CDR) to predict 1-month serious outcome and all-cause death in patients presenting with syncope to the emergency department. ⋯ The ROSE rule has excellent sensitivity and negative predictive value in the identification of high-risk patients with syncope. As a component, BNP seems to be a major predictor of serious cardiovascular outcomes and all-cause death. The ROSE rule and BNP measurement might be valuable risk stratification tools in patients with emergency presentations of syncope and should now be subjected to external validation.