Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Mar 2008
Atrial fibrillation in patients with Brugada syndrome relationships of gene mutation, electrophysiology, and clinical backgrounds.
The goal of our work was to examine the relationships of atrial fibrillation (AF) with genetic, clinical, and electrophysiological backgrounds in Brugada syndrome (BrS). ⋯ Spontaneous AF and VF are closely linked clinically and electrophysiologically in BrS patients. Patients with spontaneous AF have more severe clinical backgrounds in BrS. SCN5A mutation is associated with electrical abnormality but not disease severity.
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J. Am. Coll. Cardiol. · Mar 2008
Randomized Controlled Trial Comparative StudyDirect stenting for stable angina pectoris is associated with reduced periprocedural microcirculatory injury compared with stenting after pre-dilation.
We conducted a randomized study to compare the effect of direct stenting (DS) and conventional stenting (CS) on post-procedural index of microcirculatory resistance (IMR) values. ⋯ In patients undergoing successful coronary stenting for stable angina, DS is associated with reduced microvascular dysfunction induced by PCI as compared with CS.
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J. Am. Coll. Cardiol. · Mar 2008
Randomized Controlled Trial Multicenter StudyRandomized controlled trial of an implantable continuous hemodynamic monitor in patients with advanced heart failure: the COMPASS-HF study.
The purpose of this study was to determine whether a heart failure (HF) management strategy using continuous intracardiac pressure monitoring could decrease HF morbidity. ⋯ The implantable continuous hemodynamic monitor-guided care did not significantly reduce total HF-related events compared with optimal medical management. Additional trials will be necessary to establish the clinical benefit of implantable continuous hemodynamic monitor-guided care in patients with advanced HF.
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J. Am. Coll. Cardiol. · Mar 2008
Pre-operative N-terminal pro-brain natriuretic peptide predicts outcome in type A aortic dissection.
Acute Stanford type A aortic dissection (AAD) is associated with substantial perioperative mortality and morbidity. ⋯ Pre-operative NT-proBNP predicts outcome in patients undergoing surgery of AAD.
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J. Am. Coll. Cardiol. · Feb 2008
Meta AnalysisAntiarrhythmic effect of statin therapy and atrial fibrillation a meta-analysis of randomized controlled trials.
To improve the evaluation of the possible antiarrhythmic effect of statins, we performed a meta-analysis of randomized trials with statins on the end point of incidence or recurrence of atrial fibrillation (AF). ⋯ Use of statins was significantly associated with a decreased risk of incidence or recurrence of AF in patients in sinus rhythm with a history of previous AF or undergoing cardiac surgery or after acute coronary syndrome.