Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Jul 2007
Randomized Controlled Trial Multicenter Study Comparative StudyLack of evidence of a clopidogrel-statin interaction in the CHARISMA trial.
The purpose of this study was to evaluate the potential impact of clopidogrel and statin interaction in a randomized, placebo-controlled trial with long-term follow-up. ⋯ Despite theoretic concerns and ex vivo testing suggesting a potential negative interaction with concomitant clopidogrel and CYP3A4-MET statin administration, there was no evidence of an interaction clinically in a large placebo-controlled trial with long-term follow-up.
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J. Am. Coll. Cardiol. · Jul 2007
Randomized Controlled Trial Multicenter StudyPrognostic value of B-Type natriuretic peptides in patients with stable coronary artery disease: the PEACE Trial.
The purpose of this study was to assess the association between B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and the incidence of specific cardiovascular events in low-risk patients with stable coronary disease, the incremental prognostic information obtained from these two biomarkers compared with traditional risk factors, and their ability to identify patients who may benefit from angiotensin-converting enzyme (ACE) inhibition. ⋯ In low-risk patients with stable coronary artery disease and preserved ventricular function, BNPs provide strong and incremental prognostic information to traditional risk factors.
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J. Am. Coll. Cardiol. · Jul 2007
Obesity is a major determinant of radiation dose in patients undergoing pulmonary vein isolation for atrial fibrillation.
This study sought to evaluate the impact of obesity on patient radiation dose during atrial fibrillation (AF) ablation procedures under fluoroscopic guidance. ⋯ Obese patients receive more than twice the effective radiation dose of normal-weight patients during AF ablation procedures. Obesity needs to be considered in the risk-benefit ratio of AF ablation and should prompt further measures to reduce radiation exposure.