Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Dec 1999
Randomized Controlled Trial Comparative Study Clinical TrialNonadherence with angiotensin-converting enzyme inhibitor therapy: a comparison of different ways of measuring it in patients with chronic heart failure.
This study was designed to compare different proposed methods of assessing adherence with angiotensin-converting enzyme (ACE) inhibitor (ACEI) therapy in chronic heart failure. ⋯ All six tests distinguished full nonadherence from all other forms of adherence. The rank order of performance was plasma AcSDKP, urine AcSDKP, serum ACE, AII/AI ratio and plasma AII followed by plasma AI.
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J. Am. Coll. Cardiol. · Dec 1999
Comparative Study Clinical TrialClopidogrel as adjunctive antiplatelet therapy during coronary stenting.
We examined the procedural and 30-day clinical outcomes among patients receiving aspirin and either ticlopidine or clopidogrel during coronary stenting. ⋯ In this analysis the antiplatelet combination therapy of aspirin-plus-clopidogrel was an effective regimen for preventing thrombotic complications and major adverse cardiovascular events among a broad spectrum of patients undergoing coronary artery stenting.
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J. Am. Coll. Cardiol. · Dec 1999
Comparative StudyEchocardiographic predictors of left ventricular outflow tract obstruction and systolic anterior motion of the mitral valve after mitral valve reconstruction for myxomatous valve disease.
To determine predictors of systolic anterior motion and left ventricular outflow tract obstruction (SAM/LVOTO) after mitral valve repair (MVRep) in patients with myxomatous mitral valve disease. ⋯ These data suggest that TEE analysis of the mitral apparatus can identify patients likely to develop SAM/LVOTO after MVRep for myxomatous valve disease. The findings are consistent with the concept that SAM of mitral leaflets is due to anterior malposition of slack mitral leaflet portions into the LVOT. The position of the coaptation point of the mitral leaflets is dynamic and a potential target and end point for surgical designs to prevent SAM/LVOTO post MVRep.
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J. Am. Coll. Cardiol. · Dec 1999
Comparative StudyFamilial polymorphic ventricular arrhythmias: a quarter century of successful medical treatment based on serial exercise-pharmacologic testing.
We sought to determine whether objective tests of antiarrhythmic drug efficacy could produce favorable short- and long-term outcomes in a family with idiopathic malignant ventricular arrhythmias. ⋯ This family appears to have catecholamine hypersensitivity as the basis for their ventricular arrhythmias. Guided therapy using serial exercise-pharmacologic testing provided reliable protection for this familial ventricular arrhythmia during a 25-year follow-up.
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J. Am. Coll. Cardiol. · Nov 1999
Pulmonary hypertension and exercise intolerance in patients with heart failure.
This study was undertaken to investigate the relationship between pulmonary hypertension and exercise performance in patients with heart failure. ⋯ Pulmonary vascular resistance is frequently increased in heart failure and is associated with a reduced cardiac output response to exercise, suggesting that pulmonary hypertension impairs exercise performance in heart failure.