Neurourology and urodynamics
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We investigated the invitro effects of local anesthetics on the contractility of the human bladder. ⋯ Our study demonstrates that local anesthetics have inhibitory effects on the contraction of human bladder as induced by different stimulants and concentrations. Their effects and differences suggest that they may be considered potentially useful as diagnostic and therapeutic agents for bladder dysfunction.
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To establish normative current perception threshold (CPT) values with neuroselective sine-wave current in the lower urinary tract and to compare these values with square-wave current CPTs. ⋯ We described normative values in young healthy volunteers at three sites in the LUT using sine-wave current. Although this type of current is said to be neuroselctive, this needs to be confirmed. Stimulation with sine-wave current is different and might be more physiologic compared to square-wave stimulation. Our data show that sine-wave current stimulation at 5 Hz, 250 Hz, and 2000 Hz can probably not be used as a semi-objective measurement of the sensation of bladder filling because no correlation was found between CPTs and the cystometeric sensation of filling.