Journal of hypertension
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Journal of hypertension · Jun 2015
4A.01: LONG-TERM EFFECTS OF RENAL ARTERY DENERVATION IN REAL WORLD PATIENTS WITH UNCONTROLLED HYPERTENSION FROM THE GLOBAL SYMPLICITY REGISTRY.
The Global SYMPLICITY Registry (GSR) provides real world experience regarding the effects of radiofrequency denervation of the renal artery nerves in patients with uncontrolled hypertension. These data in hypertensive patients with a high proportion of concomitant conditions also characterized by sympathetic nervous system will further characterize the effects of renal denervation across a diverse patient population. ⋯ Renal denervation in a large real world population resulted in significant blood pressure reductions 1 year post-procedure. There were no long-term safety concerns following the denervation procedure. These data, including analysis of the BP-lowering effects of RDN in select subgroups, will be updated with two year follow-up of approximately 600 patients in June.
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Journal of hypertension · Jun 2015
8B.04: RENAL ARTERY DENERVATION FOR TREATMENT OF HYPERTENSIVE PATIENTS WITH OR WITHOUT OBSTRUCTIVE SLEEP APNEA AND RESISTANT HYPERTENSION: RESULTS FROM THE GLOBAL SYMPLICITY REGISTRY.
Obstructive sleep apnea (OSA) is associated with sympathetic nervous system activation and the development of hypertension. The Global SYMPLICITY Registry is prospectively enrolling real world patients with uncontrolled hypertension including patients with OSA. This analysis compares baseline characteristics and blood pressure (BP) lowering effects of renal denervation in patients with and without OSA. ⋯ Renal denervation resulted in significant 6-month BP reductions in patients with and without OSA but there was not a significant difference in the BP change between the 2 groups. Data from a larger cohort of 2100 patients will be presented.
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Journal of hypertension · Jun 2015
4A.09: SAFETY AND PERFORMANCE OF THE ENLIGHTN RENAL DENERVATION SYSTEM IN PATIENTS WITH SEVERE UNCONTROLLED HYPERTENSION: 12 MONTH RESULTS FROM THE ENLIGHTN II STUDY.
Percutaneous sympathetic renal artery denervation is available for the treatment of patients with resistant hypertension. We further investigated the safety and efficacy of a multi-electrode renal denervation system (EnligHTN™) in patients with severe uncontrolled hypertension. ⋯ In this real world, post-marketing study we demonstrate that multi-electrode renal denervation results in durable, highly significant and safe lowering of both office BP and ambulatory BP parameters in patients with severe uncontrolled hypertension up to 12 months following treatment.
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Journal of hypertension · Jun 2015
6A.09: DIAGNOSIS OF SODIUM SENSITIVITY FROM MEAN ARTERIAL PRESSURE MEASURED AT THE ARM OR AT THE FINGER.
The severity of sodium sensitivity is quantified or 1) by the difference in mean arterial pressure (MAP) between high- and low-sodium diets (δMAP), or 2) by the sodium-sensitivity index (SSI), i.e. ratio between δMAP and the difference in urinary sodium excretion rates at the end of the two diets. MAP is usually measured with an arm cuff but the use of finger blood pressure monitors is rapidly increasing. Thus, our aim is to evaluate whether finger measures of MAP can be reliably used for assessing sodium sensitivity. ⋯ : The assessment of sodium sensitivity depends strongly on the MAP measurement site, with important discrepancies between brachial and finger measures.
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Journal of hypertension · Jun 2015
2D.03: IMPROVING DIAGNOSTIC STRATEGY IN PATIENTS WITH LONG-STANDING HYPERTENSION, CHEST PAIN AND NORMAL RESTING ECG: VALUE OF THE EXERCISE HIGH-FREQUENCY QRS VERSUS ST-SEGMENT ANALYSIS.
The novel exercise computer-assisted high-frequency QRS-analysis (ex-HF/QRS) has demonstrated improved sensitivity and specificity over the conventional exercise-ST/ECG-segment-analysis (ex-ST/ECG) in the detection of myocardial ischemia. The aim of the present study was to test the implementation in diagnostic value of the ex-HF/QRS in patient with hypertension and chest pain (CP) versus the conventional ex-ST/ECG anlysis alone. ⋯ In patients with long-standing hypertension and CP submitted to risk stratification with exercise tolerance test, the novel ex-HF/QRS shows a valuable incremental diagnostic value over ex-ST/ECG.