Journal of hypertension
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Journal of hypertension · Jun 2015
1C.07: PRONEUROTENSIN INDEPENDENTLY PREDICTS CARDIOVASCULAR DISEASE. THE MALMÖ PREVENTIVE PROJECT.
Neurotensin is released from the gut after fat intake and has a role in appetite regulations. Proneurotensin is a stable fragment of the neurotensin precursor hormone and fasting plasma proneurotensin levels have shown to be significantly associated with the development of cardiovascular disease in middle aged participants of the Malmö Diet and Cancer Study. Here, we aimed at replicating the initial findings in an independent second cohort and to extend its validity to an older population. ⋯ Fasting proneurotensin levels are independently associated with the risk of developing cardiovascular disease which replicates the findings in MDC study.
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Journal of hypertension · Jun 2015
2D.06: IN HYPERTENSIVE PATIENTS WITH CHEST PAIN AND NORMAL RESTING ECG THE LOW-COST EXERCISE HIGH-FREQUENCY QRS-ANALYSIS IS COMPARABLE TO THE EXERCISE ECHO.
The novel exercise computer-assisted high-frequency QRS-analysis (ex-HF/QRS) has demonstrated improved sensitivity and specificity over the conventional ST/ECG-segment analysis (ex-ST/ECG) in the detection of myocardial ischemia. The aim of the present study was to compare the diagnostic value of the validated exercise-Echocardiography (ex-Echo), needing skilled cardiologist, with the novel low-cost ex-HF/QRS, including the conventional ST-segment analysis. ⋯ In "intermediate-risk" CP patients, the novel ex-HF/QRS was a valuable diagnostic tool in the crowed Emergency Departments. The test might be proposed to avoid additional costly imaging also because it did not require specialized personnel. However, additional study are needed before it can be recommended as a replacement for current techniques.
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Journal of hypertension · Jun 2015
4D.04: TIMING OF THE CAROTID PRESSURE WAVE INFLECTION POINT IS COUPLED TO SYSTOLIC MYOCARDIAL MOTION IN OLDER PATIENTS WITH CARDIOVASCULAR RISK FACTORS.
Cardiac motion during systole has been shown to be closely associated with carotid pressure wave inflection point timing in young, healthy volunteers. In these individuals the inflection point occurred following the systolic pressure peak (Murgo Type C). The relationship between myocardial motion and the timing of inflection point in older patients with cardiovascular risk factors where the inflection point precedes peak systolic pressure remains unknown. ⋯ : Peak systolic mitral annular motion timing (representing the commencement of myocardial deceleration in systole) always precedes and remains coupled to carotid pressure wave inflection point timing in older patients with established cardiovascular risk factors. This data suggests that the morphology of the central blood pressure waveform may relate more strongly to local ventricular-vascular interactions, rather than wave reflections.
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Journal of hypertension · Jun 2015
2D.03: IMPROVING DIAGNOSTIC STRATEGY IN PATIENTS WITH LONG-STANDING HYPERTENSION, CHEST PAIN AND NORMAL RESTING ECG: VALUE OF THE EXERCISE HIGH-FREQUENCY QRS VERSUS ST-SEGMENT ANALYSIS.
The novel exercise computer-assisted high-frequency QRS-analysis (ex-HF/QRS) has demonstrated improved sensitivity and specificity over the conventional exercise-ST/ECG-segment-analysis (ex-ST/ECG) in the detection of myocardial ischemia. The aim of the present study was to test the implementation in diagnostic value of the ex-HF/QRS in patient with hypertension and chest pain (CP) versus the conventional ex-ST/ECG anlysis alone. ⋯ In patients with long-standing hypertension and CP submitted to risk stratification with exercise tolerance test, the novel ex-HF/QRS shows a valuable incremental diagnostic value over ex-ST/ECG.
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Journal of hypertension · Jun 2015
5A.01: CORONARY ATHEROSCLEROSIS AND ADVERSE OUTCOME IN HYPERTENSIVE PATIENTS WITH RECENT-ONSET ATRIAL FIBRILLATION AND TROPONIN RISE.
Atrial fibrillation (AF), the most common cardiac-arrhythmia in critical-care, has reached a high prevalence in hypertensive patients. Prevention of systemic-embolism is mandatory; unfortunately, evidence to support the treatment of comorbidities as coronary artery disease (CAD) that contribute to excess mortality is lacking, and the mechanism underlying the troponin-rise during AF without acute coronary syndrome (ACS) is unclear. This study investigates the relationship between CAD, stroke and outcomes in patients with troponin-rise and AF. ⋯ Patients with a recent-onset AF and troponin-rise showed a high prevalence of CVE but not stroke, thus CAD might have a role in poor outcomes.