Resuscitation
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Management of septic shock (SS) with a norepinephrine (noradrenaline)-based haemodynamic algorithm. ⋯ In conclusion, our data support extended use of an algorithm based on norepinephrine for treating septic shock patients. This is the first clinical study that uses NE as the initial vasopressor drug systematically, and although not comparative, the mortality rates adjusted to APACHE II, are comparable to other studies. It also gives support for future clinical trials comparing norepinephrine with dopamine in this setting.
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Comparative Study
Echocardiographic comparison of cardiopulmonary resuscitation (CPR) using periodic acceleration (pGz) versus chest compression.
This investigation compared the effects of conventional cardiopulmonary resuscitation (CPR) using an automated Thumper chest compression device to periodic acceleration CPR (pGz-CPR) on early post-resuscitation ventricular function assessed by echocardiography, in an adult pig model of CPR. ⋯ pGz holds promise as a new method for CPR with better left ventricular (LV) function post-CPR than the more traditional chest compression method.
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Randomized Controlled Trial Clinical Trial
Effect of an inspiratory impedance threshold device on hemodynamics during conventional manual cardiopulmonary resuscitation.
In animals in cardiac arrest, an inspiratory impedance threshold device (ITD) has been shown to improve hemodynamics and neurologically intact survival. The objective of this study was to determine whether an ITD would improve blood pressure (BP) in patients receiving CPR for out-of-hospital cardiac arrest. ⋯ Use of the active ITD was found to increase systolic pressures safely and significantly in patients in cardiac arrest compared with sham controls.
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To evaluate the retention of CPR skills 12 months after initial training, using a manikin equipped with a computer-based voice advisory feedback system. ⋯ Computer-based voice advisory feedback can improve the performance of basic life support skills on a manikin with no deterioration in feedback supported performance after 12 months.