Resuscitation
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Multicenter Study
Post-Resuscitation Arterial Oxygen and Carbon Dioxide and Outcomes after Out-of-Hospital Cardiac Arrest.
To determine if arterial oxygen and carbon dioxide abnormalities in the first 24h after return of spontaneous circulation (ROSC) are associated with increased mortality in adult out-of-hospital cardiac arrest (OHCA). ⋯ In the first 24h after ROSC, abnormal post-arrest oxygen and carbon dioxide tensions are associated with increased out of-hospital cardiac arrest mortality.
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Randomized Controlled Trial Multicenter Study
Simulation training to improve 9-1-1 dispatcher identification of cardiac arrest: a randomized controlled trial.
The objective of this study was to test the effectiveness of simulation training, using actors to make mock calls, on improving Emergency Medical Dispatchers' (EMDs) ability to recognize the need for, and reduce the time to, telephone-assisted CPR (T-CPR) in simulated and real cardiac arrest 9-1-1 calls. ⋯ http://www.clinicaltrials.gov Trial # NCT01972087.
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Multicenter Study
Descriptive Analysis of Extracorporeal Cardiopulmonary Resuscitation Following Out-of-Hospital Cardiac Arrest - An ELSO Registry Study .
Extracorporeal cardiopulmonary resuscitation (ECPR) is an emerging therapy for refractory cardiac arrest. The purpose of this study was to analyze and report characteristics and outcomes of adult patients treated with ECPR after out-of-hospital cardiac arrest (OHCA) in a large international registry. ⋯ This international analysis of ECPR for refractory OHCA reveals a survival rate of 27.6%, demonstrates association of male gender with mortality, and highlights regional differences in PCI utilization. These results will help inform implementation and research of this potentially life-saving strategy for refractory OHCA.
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Randomized Controlled Trial Multicenter Study
Head computed tomography for prognostication of poor outcome in comatose patients after cardiac arrest and targeted temperature management.
A multimodal approach to prognostication of outcome after cardiac arrest (CA) is recommended. Evidence for combinations of methods is low. In this post-hoc analysis we described findings on head computed tomography (CT) after CA. We also examined whether generalised oedema on CT alone or together with the biomarker Neuron-specific enolase (NSE) could predict poor outcome. ⋯ In this study, generalised oedema was more common >24h≤7d after CA. The combination of CT and NSE improved sensitivity and specificity compared to CT alone, with no false positives in this limited population.
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Multicenter Study Observational Study
Incidence and outcome of in-hospital cardiac arrest in Italy: a multicentre observational study in the Piedmont Region.
to report the incidence, characteristics, and outcome of in-hospital cardiac arrest (IHCA) in a large Italian region. ⋯ in this Italian registry the incidence of IHCA and its circadian distribution were comparable to those in the NCAA registry in the UK. Patients were older and had a lower ROSC rate than these observed in other large IHCA registries, but post-ROSC survival rate and factors affecting survival to discharge were similar.