Upsala journal of medical sciences
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Phlegmonous gastritis is a rare inflammatory lesion in which bacterial infection occurs in the gastric wall. A case of phlegmonous gastritis producing an intramural filling defect in the stomach is presented. Endoscopy showed edematous and reddened gastric mucosa with a mass lesion in the gastric body and antrum. ⋯ The most important differential diagnosis is carcinoma, especially scirrhous-type gastric cancer. Radiographic findings of phlegmonous gastritis resemble those of scirrhous gastric cancer. More frequent recognition of this disease, early diagnosis and prompt institution of treatment is essential.
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Infantile fibrosarcoma is a rare soft tissue malignant tumor, when it occurs, it is usually seen in the first year of life. The clinical course of infantile fibrosarcoma is more favorable and metastasis is rare compared with that in adulthood. ⋯ Standard treatment is primarily wide surgical excision. In this case report, we present our experience of an infantile fibrosarcoma of thigh with good clinical course 36 months after tumor resection and the usefulness of detecting the ETV6-NTRK3 gene fusion in differential diagnosis.
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This is a personal account of how studies of the pharmacology of opiates led to the discovery of a family of endogenous opioid peptides, also called endorphins. The unique pharmacological activity profile of opiates has an endogenous counterpart in the enkephalins and beta-endorphin, peptides which also are powerful analgesics and euphorigenic agents. The enkephalins not only act on the classic morphine (mu-) receptor but also on the delta-receptor, which often co-exists with mu-receptors and mediates pain relief. ⋯ Both dynorphins and nociceptin have modulatory effects on several CNS functions, including memory acquisition, stress and movement. In conclusion, a natural product, morphine and a large number of synthetic organic molecules, useful as drugs, have been found to probe a previously unknown physiologic system. This is a unique development not only in the neuropeptide field, but in physiology in general.
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Human papillomaviruses (HPVs) comprise a large group of small DNA tumor viruses with tropism for squamous epithelial cells. The papillomavirus life cycle is strictly linked to the epithelial differentiation program and production of virus particles is dependent on terminal cell differentiation. The virus structural proteins L1 and L2 are therefore detected only in the upper layers with differentiated cells in the infected epithelium. ⋯ It is reasonable to speculate that the differentiation dependent production of L1 and L2 and the differences in L1 and L2 protein levels among various HPV types reflect an adaptation of the viruses to the environment of the host that results in escape from the immune surveillance for various periods of time and efficient transmission of virus in the human population. Our research group is interested in the regulation of expression of the HPV structural proteins L1 and L2. The results of our research are summarised in this article.
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A relationship has previously been described between individual mean isoflurane concentrations and the release of a marker of neuronal injury, adenylate kinase (AK), into the cerebrospinal fluid (CSF) after anaesthesia and orthognathic surgery. Likewise, reduced mental performance has been detected. Twenty-nine patients scheduled for orthognathic surgery were assigned to isoflurane- or propofol based anaesthesia, which was adjusted to a defined level with the aid of processed EEG and quantitative surface EMG. ⋯ When five of the failed patients were re-examined 12-30 months later, three patients still performed poorly in the tests. Biochemical and neuropsychological disturbances were recorded in several patients objected to orthognathic surgery. The underlying mechanisms are unclear, including the role of the anaesthetic drugs or surgery itself.