Pediatric dermatology
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Lichen striatus is a self-limiting inflammatory condition of unknown etiology in which the lesions follow the lines of Blaschko. We report a series of 61 cases of this condition in children, describing the clinical features, age distribution, and season of onset. The preponderance of cases in the preschool-age group and onset in the spring and summer months support the hypothesis of an environmental agent, possibly an infection, in the etiology of the condition.
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Pediatric dermatology · Dec 1995
Case ReportsCongenital ventral hernia in association with focal dermal hypoplasia.
Focal dermal hypoplasia is a rare, X-linked dominant syndrome characterized by dysplasia of the skin, skeleton, and central nervous system. We report an infant who was born with severe focal dermal hypoplasia and an epigastric hernia. Operative timing and approach to abdominal wall defects in the presence of severe cutaneous dysplasia are discussed.
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Pediatric dermatology · Jun 1994
Case ReportsLinear IgA bullous dermatosis of childhood with autoantibodies to a 230 kDa epidermal antigen.
Linear IgA bullous dermatosis (LABD) is an autoimmune, subepidermal disease defined on the basis of direct immunofluorescence findings. However, more recent techniques used to study bullous dermatoses suggest that LABD may be heterogeneous. A patient with LABD of childhood (chronic benign disease of childhood, CBDC) was studied by indirect immunofluorescence on salt-split skin and by Western blot in an attempt to characterize the involved autoantigen. ⋯ Indirect immunofluorescence revealed circulating IgA autoantibodies that reacted with the epidermal side of salt-split skin; these reacted by Western blot with a 230 kDa epidermal antigen, as in bullous pemphigoid. This case, fulfilling the diagnostic clinical and direct immunofluorescence criteria for LABD/CBDC, seems to represent IgA bullous pemphigoid. It further underscores the nosologic heterogeneity of LABD, which probably includes, apart from bullous pemphigoid, epidermolysis bullosa acquisita and cicatricial pemphigoid.
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A newborn black boy had two facial blisters at birth that progressed to bullous lesions over the trunk, genitals, extremities, and oral and tracheal mucosa. A biopsy specimen demonstrated a subepidermal bulla with mixed eosinophilic and neutrophilic, inflammatory infiltrate. ⋯ This is the youngest reported patient with the disease. Linear IgA bullous dermatosis should be considered in the differential diagnosis of blistering diseases of the newborn, and immunofluorescence should be performed on a skin biopsy specimen.
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Pediatric dermatology · Sep 1992
Case ReportsPainful, plaque-like, pitted keratolysis occurring in childhood.
Pitted keratolysis is a superficial infection of the soles of the feet that is almost always asymptomatic. A painful variant of this disorder was reported to occur in adult males during military service. We report painful, plaque-like, pitted keratolysis in two children. Treatment with topical erythromycin was curative.