Vaccine
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Oral polio vaccine has reduced the incidence of polio in India and many states have been polio free for a long time while occasional polio cases are occurring in some states. On the other hand more than 96% of polio cases being reported in India are occurring in Uttar Pradesh and Bihar. The current polio scenario indicates that oral polio vaccines cannot eradicate polio from Uttar Pradesh and Bihar because some children from these two states show poor response to OPV. There is an urgent need for re-appraisal of polio eradication strategy.
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Randomized Controlled Trial Comparative Study
Immunogenicity and safety of low dose virosomal adjuvanted influenza vaccine administered intradermally compared to intramuscular full dose administration.
Despite the established benefit of intramuscular (i.m.) influenza vaccination, new adjuvants and delivery methods for comparable or improved immunogenicity are being explored. Intradermal (i.d.) antigen administration is hypothesized to initiate an efficient immune response at reduced antigen doses similar to that observed after i.m. full dose vaccination. ⋯ The virosomal adjuvanted influenza vaccine (Inflexal V) was shown to be overall highly immunogenic and well tolerated when given i.d. at reduced doses to healthy adults, eliciting an immune response similar to that observed with full dose i.m. administration and thus suggesting a promising antigen-sparing strategy for universal influenza vaccination against endemic influenza.