Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
-
Comparative Study
Prognostic factors in lung cancer with brain metastasis.
Metastasis to the brain develops in 25% of all patients with lung cancer. Although the outcome is usually poor, there seems to be a subset of patients with favorable prognostic factors who may live longer. Prognostic factors were analyzed retrospectively in 103 patients with brain metastases from lung carcinoma to identify patients who would benefit from more intensive treatment strategies. ⋯ The presence of symptoms related to the primary tumor at the time of brain metastasis is one of the factors that can be used to distinguish patients with a favorable outcome. In patients with favorable prognostic factors and thus longer survival probability, the role of boost dose after whole brain radiotherapy or surgical resection in suitable cases needs to be investigated.
-
Comparative Study
Conservative surgery and radiotherapy in early stage breast cancer: a comparison between tumourectomy and quadrantectomy.
This study analyses and compares the results of local regional control, distant metastases and survival in two series of patients irradiated from 1986 to 1992 in our radiation oncology centre following quadrantectomy or tumourectomy for early stage breast cancer. ⋯ Our findings show that tumourectomy and quadrantectomy, followed by adequate radiotherapy, provide comparable results in terms of local-regional control and survival.
-
Comparative Study
Non-coplanar beam intensity modulation allows large dose escalation in stage III lung cancer.
To evaluate the feasibility of dose escalation in stage III non-small cell lung cancer, we compared standard coplanar (2D) with non-coplanar beam arrangements, without (3D) and with beam intensity modulation (3D-BIM). ⋯ The potential of 3D-BIM for dose escalation is explained as follows: (i) compared to other planning techniques, a larger amount of lung tissue can be spared by using beam directions that are well-aligned with the mediastinal structures. Such beam directions have narrow angles with the sagittal plane; (ii) dividing all beams into segments with well-specified geometrical restrictions in relation to the spinal cord and well-defined relative weights results in a lower dose to the spinal cord.
-
Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
A phase III double-blind randomised study of rectal sucralfate suspension in the prevention of acute radiation proctitis.
A limited number of studies have suggested that oral sucralfate reduces the acute and late gastro-intestinal side-effects of pelvic radiotherapy and sucralfate enemas ameliorate symptoms of chronic proctitis. Sucralfate may act via local bFGF at the mucosal level in promoting angiogenesis and reducing epithelial associated microvascular injury. This multi-institutional study was designed to test the hypothesis that sucralfate given as an enema would have a significant protective effect against acute radiation induced rectal injury by direct application to the mucosa. ⋯ This study suggests that sucralfate given as a once daily enema does not substantially reduce the incidence of symptoms associated with acute radiation proctitis and its routine clinical use cannot be recommended. This cohort of patients will be followed to determine if any difference develops in relation to late toxicity.
-
Randomized Controlled Trial Comparative Study Clinical Trial
Prophylactic use of tropisetron or metoclopramide during adjuvant abdominal radiotherapy of seminoma stage I: a randomised, open trial in 23 patients.
Nausea and vomiting are frequent side effects during adjuvant abdominal radiotherapy in seminoma stage I patients. This study evaluates the efficacy and side effects of prophylactically administered tropisetron in comparison to metoclopramide. ⋯ Seminoma stage I patients on tropisetron experienced less nausea and vomiting during abdominal radiotherapy than patients receiving metoclopramide. The costs of the former drug may, however, not justify its use as first choice anti-emetic since few patients in either group experienced severe nausea.