European journal of anaesthesiology
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Randomized Controlled Trial Comparative Study Clinical Trial
General anaesthesia combined with bilateral paravertebral blockade (T5-6) vs. general anaesthesia for laparoscopic cholecystectomy: a prospective, randomized clinical trial.
The efficiency of bilateral paravertebral blockade combined with general anaesthesia (active) vs. general anaesthesia alone (control) in reducing postoperative pain following laparoscopic cholecystectomy was evaluated using a prospective randomized study design. ⋯ When used as a complement to general anaesthesia, bilateral nerve-stimulator guided paravertebral blockade with lidocaine, bupivacaine, fentanyl and clonidine may improve postoperative pain relief.
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Randomized Controlled Trial Comparative Study Clinical Trial
Ibuprofen vs. acetaminophen vs. ibuprofen and acetaminophen after arthroscopically assisted anterior cruciate ligament reconstruction.
The analgesic potency of non-steroidal anti-inflammatory drugs and acetaminophen are still being debated. We have assessed the relative analgesic effect of ibuprofen, acetaminophen or the combination of both after orthopaedic surgery. ⋯ Ibuprofen 800 mg thrice daily reduced pain to a greater degree than acetaminophen 1 g thrice daily, after anterior cruciate ligament reconstruction under general anaesthesia. The combination of acetaminophen and ibuprofen did not provide any superior analgesic effect.
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Randomized Controlled Trial Comparative Study Clinical Trial
Comparative assessment of the effects of alfentanil, esmolol or clonidine when used as adjuvants during induction of general anaesthesia.
This randomized, double-blinded, prospective study compared the effects of clonidine, esmolol or alfentanil on the level of hypnosis and haemodynamic responses to intravenous induction of anaesthesia and endotracheal intubation. ⋯ None of the study drugs blocked the increase in mean arterial pressure induced by endotracheal intubation, but esmolol provided better overall haemodynamic stability. All groups had an adequate level of hypnosis.
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Randomized Controlled Trial Comparative Study Clinical Trial
Air leakage around endotracheal tube cuffs.
To compare the recently introduced Microcuff endotracheal tube with conventional tubes in respect of the cuff pressures required to prevent air leakage. ⋯ The Microcuff endotracheal tube with its ultra-thin polyurethane cuff membrane required the lowest sealing pressure to prevent air leakage. These features are potentially of interest for long-term intubated patients and for cuffed endotracheal tubes in children, allowing tracheal sealing at lower cuff pressures implying less damage to the trachea.