European journal of anaesthesiology
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Comparative Study
Hyperalgesia and increased sevoflurane minimum alveolar concentration induced by opioids in the rat: A randomised experimental study.
Perioperative opioids reduce inhalational anaesthetic requirements. The initial hypoalgesia may, however, be followed by a rebound hyperalgesia. ⋯ Opioid-induced hyperalgesia was associated with an increase in the MAC in normal rats who had not undergone surgery. Both effects lasted 21 days and were prevented by ketamine.
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Unrelieved acute postoperative pain can lead to a wide range of adverse effects, such as anxiety, depression, restlessness and sleep deprivation. ⋯ We report that a rat model of acute postoperative pain is associated with anxiety-like increased light and open arm avoidance behaviour.
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Historical Article
The challenges of anaesthesia for the next decade: A personal view.
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Randomized Controlled Trial Comparative Study
Ultrasound versus fluoroscopic-guided epidural steroid injections in patients with degenerative spinal diseases: A prospective, randomised study.
Epidural steroid injections are routinely performed under fluoroscopic guidance, but could also be performed using preprocedure ultrasound spine examination. ⋯ We have demonstrated the feasibility of ultrasound-assisted epidural steroid injections.
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Observational Study
Hyperalgesia induced by low-dose opioid treatment before orthopaedic surgery: An observational case-control study.
Chronic pain and opioid consumption may trigger diffuse hyperalgesia, but their relative contributions to pain vulnerability remain unclear. ⋯ Chronic pain patients treated with low doses of opioid had hyperalgesia before surgery. These results highlight the need to personalise the management of patients treated with opioids before surgery.