European journal of anaesthesiology
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Eur J Anaesthesiol
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Randomized Controlled Trial
The synergistic effect of dexmedetomidine on propofol for paediatric deep sedation: A randomised trial.
Propofol and dexmedetomidine are used separately, and sometimes together, for paediatric deep sedation. Although their combination has been described in adults, the effect of dexmedetomidine as a potential synergist in children has not been studied before. ⋯ The combination of dexmedetomidine and propofol for paediatric procedural sedation achieved a significant reduction in median propofol dose and a slightly shorter median time to discharge from PACU. Large-scale studies may determine whether this reduction decreases the risk of significant adverse events.