European journal of anaesthesiology
The most recent articles from:
Eur J Anaesthesiol
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Editorial Historical Article
History of anaesthesia: Datex. A Finnish success story in anaesthesia monitoring.
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Randomized Controlled Trial
Reduction in the incidence of acute kidney injury after aortic arch surgery with low-dose atrial natriuretic peptide: A randomised controlled trial.
Acute kidney injury (AKI) after surgery is associated with an increased risk of adverse events and death. Atrial natriuretic peptide (ANP) dilates the preglomerular renal arteries and inhibits the renin-angiotensin axis. A low-dose ANP infusion increases glomerular filtration rate after cardiovascular surgery, but it is not known whether it reduces the incidence of AKI or the mortality rate. ⋯ We found that an intravenous infusion of ANP at 0.0125 μg kg(-1) min(-1) is an effective intervention for reducing the incidence of postoperative AKI, and appears to afford a degree of renal protection during and after cardiovascular surgery.