European journal of anaesthesiology
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Randomized Controlled Trial
Effects of magnesium sulphate on the pharmacodynamics of rocuronium in patients aged 60 years and older: A randomised controlled study.
There is little information on the interaction between magnesium sulphate (MgSO4) and rocuronium in elderly patients. With a growing number of older patients who need surgical procedures, it is increasingly important to study this age group. ⋯ In oncology patients of 60 or more years of age, preadministration of MgSO4, with the doses used in this study, significantly reduced the onset time of NMB induced by rocuronium.
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Propofol target-controlled infusion (TCI) in effect site mode has become popular since it became commercially available. ⋯ Pharmacokinetic analysis suggests that the performance of the Marsh model in effect site mode is poor in this broad patient population. The greatest bias demonstrated occurred in the early maintenance phase of anaesthesia. Of the covariates analysed, obesity contributed most significantly to an increased bias. Despite overall poor performance of the Marsh model, attending anaesthesiologists modified targeted propofol concentrations only 0.3 times per hour on average, using remifentanil dose modification nine times more frequently, with good surgical conditions in all patients.
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Comparative Study
Effects of isoflurane-induced anaesthesia on cognitive performance in a mouse model of Alzheimer's disease: a randomised trial in transgenic APP23 mice.
Results from in-vitro experiments suggest that inhalational anaesthetics may have a detrimental effect on the course and incidence of Alzheimer's disease. However, case-control studies in humans show no negative impact of anaesthetics on the course of Alzheimer's disease. ⋯ Isoflurane may have protective, rather than detrimental, effects on cognition in Alzheimer's disease.
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Letter Randomized Controlled Trial
Impact of depth of hypnosis on immediate postoperative cognitive function: A randomised, double-blinded, prospective study.