European journal of anaesthesiology
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The bispectral index (BIS) is derived from the EEG and therefore may be useful to diagnose intraoperative cerebral ischaemia. This study was undertaken to investigate BIS changes in awake patients with and without neurological deficits during carotid endarterectomy under regional anaesthesia. ⋯ Our results describe a relationship between BIS reductions and neurological deficits during carotid surgery in awake patients.
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Microcirculatory alterations are thought to be responsible for much of the morbidity and mortality from sepsis. The aim of the present study was to characterize the buccal microvascular response in patients with septic shock using combined laser Doppler flowmetry/visual light spectroscopy measurements. ⋯ Buccal laser Doppler flowmetry/visual light spectroscopy may be useful for tracing microvascular alterations in critically ill patients. The surgical stress response was associated with alterations in local flow with preserved microHbO2. However, in patients with septic shock, microHbO2 was reduced in the deep channel, probably muscular tissue, with no changes in microvascular flow.
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Retraction Of Publication
Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 in rats: Retraction.
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Randomized Controlled Trial Comparative Study
Propofol induces endothelial nitric oxide synthase phosphorylation and activation in human umbilical vein endothelial cells by inhibiting protein kinase C delta expression.
Protein kinase Cs (PKCs) are involved in the regulation of endothelial nitric oxide synthase (eNOS). The purpose of this study is to evaluate the role of PKC delta in mediating the effects of chronic treatment with propofol on eNOS activation in human umbilical venous endothelial cells. ⋯ Propofol induces eNOS activation through a PKC delta inhibition-dependent, protein phosphatase 2A-coordinated, but phosphoinositide 3-kinase/Akt-independent pathway.
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Randomized Controlled Trial Comparative Study
Prevention of pain on injection of propofol: a comparison of lidocaine with different doses of paracetamol.
The aim of this study was to compare the efficacy of pretreatment with paracetamol 0.5 mg kg(-1), 1 mg kg(-1), 2 mg kg(-1) and lidocaine 0.5 mg kg(-1) for prevention of propofol induced pain. ⋯ When given as venous retention pretreatments 1 min before propofol, paracetamol 1 mg kg(-1) and lidocaine 0.5 mg kg(-1) were equally effective in attenuating pain during intravenous (i.v.) injection of propofol whereas pretreatment with paracetamol 2 mg kg(-1) was shown to be the most effective treatment.