ORL; journal for oto-rhino-laryngology and its related specialties
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ORL J. Otorhinolaryngol. Relat. Spec. · Jan 2003
TUNEL-positive labeling in mouse inner ear caused by tubulin immunization is not apoptosis.
Apoptosis is involved in all fundamental processes of the immune system. To study whether apoptosis plays any role in the pathogenesis of autoimmune inner ear disease, we immunized Balb/c mice with tubulin. The inner ears were examined with TUNEL (in situ terminal dUTP nick-end labeling) and immunocytochemistry of the apoptosis regulatory proteins Bcl-2 and Bax. ⋯ However, under morphological analysis by light microscope, these cells lack the features characteristic of apoptosis. Moreover, no cells staining positive for Bcl-2 and Bax are found in any structures of the inner ears. These results suggest that positive TUNEL staining in this model does not indicate apoptosis and apoptosis may be not involved in autoimmune inner ear disease.
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ORL J. Otorhinolaryngol. Relat. Spec. · Nov 2002
Case ReportsMagnetic resonance imaging and high-resolution computed tomography in the otospongiotic phase of otosclerosis.
Otosclerosis very often leads to severe hearing loss in a chronic progressive manner. In the first phase of the disease, otospongiosis causes an inflammatory osteolytic process in the osseous labyrinthine capsule. In the cases reported here, this osteolytic process was pronounced in the osseous capsule of the cochlea. High-resolution CT and MRI showed the precise localization and stage of this inflammatory-osteolytic process in the petrous bone, while scintigraphy confirmed the diagnosis.
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ORL J. Otorhinolaryngol. Relat. Spec. · Sep 1997
The impact of the measuring distance on laser-Doppler measurements of the microcirculation in human nasal mucosa. A study of rhinostereometry and micromanipulator-guided laser-Doppler flowmetry.
Fourteen healthy volunteers were examined using rhinostereometry (RSM) and micromanipulator-guided laser-Doppler flowmetry (LDF) on the inferior turbinate and nasal septum. There were significant differences of the flowmetry readings at different distances from the mucosal surface within 0-1.0 mm. ⋯ This can be a problem especially during intranasal challenges with substances that influence congestion. These artefacts can be eliminated by using an RSM-guided micromanipulator that allows the probe to follow changes in congestion.
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ORL J. Otorhinolaryngol. Relat. Spec. · Sep 1995
Mediastinal staging of non-small-cell lung cancer: computed tomography and cervical mediastinoscopy.
The exact indications for computed tomography (CT) of the thorax and mediastinoscopy (MS) in lung cancer still remain incompletely defined. The present study was designed to establish a standard approach to cervical MS for otolaryngologists, who in Denmark are traditionally involved in the staging of non-small-cell lung cancer (NSCLC). Sixty-four potentially operable patients with NSCLC underwent thoracic CT prior to bronchoscopy and cervical MS. ⋯ It is concluded that because of the relatively low sensitivity and specificity of mediastinal CT, cervical MS remains essential in the evaluation of patients with presumed or verified NSCLC and that cervical MS, in experienced hands, is a safe and accurate procedure. For Danish otolaryngologists, the strategy of routine cervical MS, performed under general anaesthesia in the same stage as bronchoscopy, is advocated as a standard approach to mediastinal assessment for the staging of NSCLC. However, thoraco-abdominal CT is advocated for all patients with NSCLC, in whom operation is contemplated, as a supplementary investigation after other routine diagnostic and staging procedures, including cervical MS, have been carried out.
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ORL J. Otorhinolaryngol. Relat. Spec. · Jul 1995
Randomized Controlled Trial Comparative Study Clinical TrialEffect of local tranexamic acid gel in the treatment of epistaxis.
In patients with nosebleedings, the hemostatic effect of local application of tranexamic acid gel or placebo was compared in a randomized, double-blind, multicenter clinical trial with parallel groups. The times needed to arrest the initial bleeding were recorded, as well as any rebleedings within 10 days. ⋯ Tranexamic acid was no better than placebo in the early treatment of nose bleedings, but the gel itself seemed to have a beneficial effect. The gel preparations were easy to insert into the nasal cavity and caused no discomfort to the patients.