Journal of hepatology
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Journal of hepatology · Oct 2004
Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow.
The study aims were to determine the role of inflammation in the pathogenesis of increased intracranial pressure (ICP) in patients with acute liver failure (ALF) and its interplay with cerebral blood flow (CBF) and ammonia. ⋯ The results of this study suggest that inflammation plays an important synergistic role in the pathogenesis of increased ICP possibly through its effects on CBF.
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Journal of hepatology · Jun 2004
Much gained by integrating contact tracing and vaccination in the hepatitis B antenatal screening program in Amsterdam, 1992-1999.
Hepatitis B control in Europe concentrates on antenatal screening to reduce vertical transmission. To reduce horizontal transmission and the pool of infectious individuals, the Municipal Health Service of Amsterdam integrated tracing and immunising of contacts in the antenatal screening program. ⋯ Tracing and immunising susceptible contacts of women screened as HBsAg-positive, should be an integral component of any country's HBV control program.
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Journal of hepatology · Apr 2004
Comment Letter Case ReportsAtorvastatin as a trigger of autoimmune hepatitis.
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Journal of hepatology · Jan 2004
Melatonin inhibits nuclear factor kappa B activation and oxidative stress and protects against thioacetamide induced liver damage in rats.
Free radical-mediated oxidative stress has been implicated in the pathogenesis of acute liver injury. The aim of our study was to investigate whether melatonin, a potent free radical scavenger could prevent fulminant hepatic failure in rats. ⋯ In a rat model of TAA-induced fulminant hepatic failure, melatonin improves survival and reduces liver damage and oxidative stress. The results suggest a causative role of oxidative stress in TAA-induced hepatic damage and suggest that melatonin may be utilized to reduce liver injury associated with oxidative stress.