Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine
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The CEST experiment, with its correlation to rare proton species that are in exchange with the water pool, is very similar to the off-resonant water spin-lock (SL) experiment. In particular, low-power SL Z-spectrum acquisition allows insight into T1ρ and exchange effects with decreased direct water saturation. Because the available SL methods either require high B1 power or are instable in the presence of strong B1 and B0 inhomogeneity present at ultra-high fields, the goal of this study was to find a robust adiabatic SL pulse for on- and off-resonant application in the human brain at 9.4 T. ⋯ By adapting a pulse shape for low-power SL experiments, we were able to acquire robust on- and off-resonant adiabatic SL prepared images in vivo at 9.4 T. This development leads directly to SL Z-spectrum acquisition, beneficial for chemical-exchange-weighted MRI.
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To enable whole-heart 3D coronary magnetic resonance angiography (CMRA) with isotropic sub-millimeter resolution in a clinically feasible scan time by combining respiratory motion correction with highly accelerated variable density sampling in concert with a novel 3D patch-based undersampled reconstruction (3D-PROST). ⋯ The proposed approach enables free-breathing whole-heart 3D CMRA with isotropic sub-millimeter resolution in <5 min and achieves improved coronary artery visualization in a short and predictable scan time.
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To develop a rapid dynamic contrast-enhanced MRI method with high spatial and temporal resolution for small-animal imaging at 7 Tesla. ⋯ This feasibility study demonstrated that the proposed 3D-UTE-GRASP method can be used for effective measurement of the 3D spatial heterogeneity of tumor pharmacokinetic parameters.