Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine
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The quality and precision of post-mortem MRI microscopy may vary depending on the embedding medium used. To investigate this, our study evaluated the impact of 5 widely used media on: (1) image quality, (2) contrast of high spatial resolution gradient-echo (T1 and T2 * -weighted) MR images, (3) effective transverse relaxation rate (R2 * ), and (4) quantitative susceptibility measurements (QSM) of post-mortem brain specimens. ⋯ Embedding media affect gradient-echo image quality, R2 * , and QSM in differing ways. In this study, PBS embedding was identified as the most stable experimental setup, although by a small margin. Agarose and Galden were preferred to formalin or D2 O embedding. Formalin significantly increased R2 * causing noisier data and increased QSM variance.
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This study aimed to develop a 3D MRI technique to assess lung ventilation in free-breathing and without the administration of contrast agent. ⋯ UTE-SENCEFUL represents a robust MRI method to assess both morphological and functional information of the lungs in 3D. When compared to the 2D approach, 3D-UTE offered ventilation maps with higher resolution, improved SNR, and reduced ventilation artifacts.
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This preclinical study investigated the use of QSM MRI to noninvasively measure venous oxygen saturation (SvO2) in the hepatic and portal veins. ⋯ QSM is a feasible tool for noninvasively measuring SvO2 in the liver and can detect differences due to increased oxygen consumption in livers bearing colorectal metastases.
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Multicenter Study
Fully convolutional networks for automated segmentation of abdominal adipose tissue depots in multicenter water-fat MRI.
An approach for the automated segmentation of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in multicenter water-fat MRI scans of the abdomen was investigated, using 2 different neural network architectures. ⋯ The segmentations generated by the U-Net allow for reliable quantification and could therefore be viable for high-quality automated measurements of VAT and SAT in large-scale studies with minimal need for human intervention. The high performance on the multicenter test data furthermore shows the robustness of this approach for data of different patient demographics and imaging centers, as long as a consistent imaging protocol is used.
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To perform multi-echo water/fat separated proton resonance frequency (PRF)-shift temperature mapping. ⋯ The proposed model-based water/fat separated algorithm produces accurate PRF-shift temperature maps in mixed water and fat tissues in the presence of spatiotemporally varying off-resonance and motion.