Anaesthesia and intensive care
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Anaesth Intensive Care · Dec 1999
Randomized Controlled Trial Comparative Study Clinical TrialPropofol-thiopentone admixture: recovery characteristics.
We have investigated, in a prospective double-blind study, recovery from anaesthesia induced by two admixtures of propofol and thiopentone and compared it with a third group of patients who received propofol and lignocaine. Ninety unpremedicated ASA 1 or 2 patients scheduled for elective gynaecological laparoscopy as a daycase procedure were randomly allocated to receive one of three different mixtures for induction of anaesthesia as part of a standardized anaesthetic: Group P50: propofol 1% 10 ml/thiopentone 2.5% 10 ml, Group P75: propofol 1% 15 ml/thiopentone 2.5% 5 ml, Group P100: propofol 1% 20 ml/lignocaine 1% 4 ml. Recovery from anaesthesia was assessed for up to four hours post-induction by critical flicker fusion threshold and best post-box toy completion time. ⋯ Nor was there any difference between the groups with respect to postoperative analgesia or anti-emetic administration. Utilizing the most sensitive end-point, a sample of nearly 1000 patients in each group would be required to confirm the observed difference with a power of 0.8 based on the data from this study. In comparison with lignocaine, the addition of thiopentone to propofol does not delay recovery from anaesthesia and does not increase postoperative analgesic or anti-emetic requirements.
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Anaesth Intensive Care · Dec 1999
Meta AnalysisThe effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on postoperative renal function: a meta-analysis.
The aim of this systematic review was to assess the effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on post-operative renal function. Eight randomized placebo-controlled double-blinded trials (n = 345) were identified from searches of MEDLINE, EMBASE and the Cochrane Controlled Trials Register databases. The summary effect size and 95% confidence intervals (95% CI) were calculated by a weighted mean difference analysis using a random-effects model. ⋯ Urine volume did not change significantly at any time. There was therefore a clinically unimportant transient reduction in renal function. NSAIDs should not be withheld from patients with normal preoperative renal function because of concerns about postoperative renal impairment.
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Anaesth Intensive Care · Dec 1999
Randomized Controlled Trial Comparative Study Clinical TrialA prospective randomized clinical assessment of a new pigtail central venous catheter in comparison with standard alternatives.
The Cook Pigtail central venous catheter (CVC) has been designed to diminish the risk of vascular perforation and consequent cardiac tamponade. With the participation of 12 consultant anaesthetists and 19 registrars, adults undergoing elective surgery were randomized to receive either a Pigtail (n = 101) or their consultant anaesthetists' "standard" CVC (n = 102). Median ease of insertion was rated 8 for Pigtail CVCs and 9 for standards (10 being best; P = 0.001). ⋯ No significant difference was found in insertion time or radiographically assessed tip depth for standard and Pigtail central venous catheters. A perforated right atrium of uncertain cause occurred in a patient who received an Arrow triple-lumen central venous catheter. Participating consultant anaesthetists preferred their "standard" central venous catheter for routine use, but five indicated that they would select a Cook Pigtail where long-term use was planned because of in vitro evidence of its greater safety.
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Anaesth Intensive Care · Dec 1999
Randomized Controlled Trial Comparative Study Clinical TrialA comparison of the reinforced and standard laryngeal mask airway: ease of insertion and the influence of head and neck position on oropharyngeal leak pressure and intracuff pressure.
We conducted a randomized, crossover study of 60 paralysed anaesthetized adult patients to compare ease of insertion for the reinforced (RLMA) and standard laryngeal mask airway (LMA). We also test the hypothesis that oropharyngeal leak pressure (OLP) and intracuff pressure (ICP) vary with head and neck position for the two devices. OLP and ICP were documented in four head and neck positions (neutral first, then flexion, extension and rotation in random order) for each device. ⋯ We conclude that ease of insertion is similar for the RLMA and LMA. OLP is higher with head/neck flexion and lower with extension for both devices and is associated with a similar change in ICP. We recommend assessing the efficacy of seal for all head and neck positions likely to be encountered prior to the start of surgery.