Anaesthesia and intensive care
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Anaesth Intensive Care · Dec 2002
Use of propofol infusion in Australian and New Zealand paediatric intensive care units.
Despite the risk of propofol infusion syndrome, a rare but often fatal complication of propofol infusion in ventilated children and possibly adults, propofol infusion remains in use in paediatric intensive care units (PICU). This questionnaire study surveys the current pattern of use of this sedative infusion in Australian and New Zealand PICUs. Thirty-three of the 45 paediatric intensive care physicians surveyed (73%), from 12 of the 13 intensive care units, returned completed questionnaires. ⋯ Knowledge of local protocols for the use of propofol infusion is associated with a significantly greater level of monitoring for possible adverse events. We suggest that national guidelines for the use of propofol infusion in children should be developed. These should include clear indications and contraindications to its use, a maximum dose rate and maximum period of infusion, with a ceiling placed on the cumulative dose given and clearly stated minimum monitoring requirements.
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Anaesth Intensive Care · Dec 2002
Randomized Controlled Trial Clinical TrialThe effects of intravenous lignocaine on haemodynamics and seizure duration during electroconvulsive therapy.
Electroconvulsive therapy (ECT) is commonly associated with acute hyperdynamic cardiovascular responses, and we hypothesize that intravenous lignocaine can blunt this response. We have measured the effect of lignocaine 1.5 mg/kg i.v. on heart rate and mean arterial pressure during electroconvulsive therapy. Furthermore, we also assessed seizure duration using both the cuff method and two-lead electroencephalography. ⋯ The use of intravenous lignocaine was, however, associated with a remarkably shortened seizure duration. Due to the reduction in seizure duration, routine administration of intravenous lignocaine may not be advisable since it may interfere with the psychotherapeutic efficacy of electroconvulsive therapy. However, intravenous lignocaine medication for electroconvulsive therapy is potentially useful for reducing tachycardia in high-risk patients and reducing the severity of propofol injection pain in comparison with a placebo.
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Anaesth Intensive Care · Dec 2002
Comparative StudyAppropriate size of laryngeal mask airway for children.
The aim of this crossover study was to determine the optimal size of laryngeal mask airway in children weighing 10 to 20 kg. In each of 67 apnoeic anaesthetized children, the size 2 and size 2 1/2 laryngeal mask airways were inserted consecutively by a skilled user and the cuff inflated to 60 cmH2O. Each LMA was assessed for the ease of insertion (by the number of attempts), oropharyngeal leak pressure, anatomical position (assessed fibreoptically) and the volume of air required to achieve intracuff pressure of 60 cmH2O. ⋯ The fibreoptic bronchoscope scores were not significantly different between the two sizes of LMAs. The volume of air to achieve intracuff pressure of 60 cmH2O was much lower than the maximum recommended volume (5.1 ml for size 2 and 6.2 ml for size 2 1/2). We conclude that the size 2 1/2 LMA provides a better fit than size 2 in children 10 to 20 kg.
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Anaesth Intensive Care · Dec 2002
Reliability of procalcitonin as a severity marker in critically ill patients with inflammatory response.
Procalcitonin (PCT) is increasingly recognised as an important diagnostic parameter in clinical evaluation of the critically ill. This prospective study was designed to investigate PCT as a diagnostic marker of infection in critically ill patients with sepsis. Eighty-five adult ICU patients were studied. ⋯ PCT showed a higher sensitivity (73% versus 35%) and specificity (83% versus 42%) compared to CRP in identifying infection as a cause of the inflammatory response. Best cut-off levels were 1.31 ng/ml for PCT and 13.9 mg/dl for CRP. We suggest that PCT is a more reliable marker than CRP in defining infection as a cause of systemic inflammatory response.
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Anaesth Intensive Care · Dec 2002
Reflex responses to insertion of the intubating laryngeal mask airway, intubation and removal of the ILMA.
We studied 21 patients (ASA 1 or 2) to investigate the skin vasomotor reflex (SVmR) and haemodynamic responses to insertion of an intubating laryngeal mask airway (ILMA), tracheal intubation using the ILMA and removal of the ILMA. Anaesthesia was induced with fentanyl, midazolam, vecuronium and nitrous oxide. A size 4 ILMA was inserted using the standard technique, and a silicone reinforced tracheal tube (7.5 mm, ID) was passed through it. ⋯ The mean amplitudes of the SVmR were 0.46 (SD 0.29), 0.54 (0.32) and 0.68 (0.21) respectively. The magnitude of the SVmR and the haemodynamic changes induced by removal of the ILMA were significantly larger than those accompanying the other two procedures. Use of the ILMA for intubation and removal of the ILMA produces three stimuli and the removal of the ILMA produces the greatest response.