Anaesthesia and intensive care
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Anaesth Intensive Care · Sep 2015
Infraclavicular axillary vein cannulation using ultrasound in a mechanically ventilated general intensive care population.
Central venous catheter (CVC) insertion is commonly undertaken in the ICU. The use of ultrasound (US) to facilitate CVC insertion is standard and is supported by guidelines. Because the subclavian vein cannot be insonated where it underlies the clavicle, its use as a CVC site is now less common. ⋯ Thirty-nine (31%) patients had a body mass index of 30 or above, 43 (34%) patients had a coagulopathy and 70 (56%) patients had significant ventilator dependence (FiO2 of 0.5 or above, or positive end expiratory pressure 10 cmH20 or above). The technique of US-guided axillary CVC access can be undertaken successfully in ventilated intensive care patients, even in challenging circumstances. Taken together with existing work on the utility and safety of this technique, we suggest that it be adopted more widely in the intensive care population.
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Anaesth Intensive Care · Sep 2015
Factors associated with vancomycin nephrotoxicity in the critically ill.
Vancomycin is a glycopeptide antibiotic commonly used in the management of methicillin-resistant Staphylococcus aureus infection. The recent increase in prevalence of methicillin-resistant Staphylococcus aureus with reduced susceptibility to vancomycin has prompted experts to advocate for higher target trough serum concentrations. This study aimed to evaluate the potential consequences of more aggressive vancomycin therapy, by examining the association between higher serum concentrations and acute kidney injury (AKI) in a population of critically ill patients. ⋯ The median age was 57 (44 to 68) years, while the median trough serum concentration was 16 (10 to 19) mg/l. Multivariate logistic regression analysis identified mean trough concentration (OR=1.174, P=0.024), APACHE II score (OR=1.141, P=0.012) and simultaneous aminoglycoside prescription (OR=18.896, P=0.002) as significant predictors of AKI. These data suggest higher trough vancomycin serum concentrations are associated with greater odds of AKI in the critically ill.
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Anaesth Intensive Care · Sep 2015
Measurement of peak aortic jet velocity in the perioperative period-machine variability: implications for assessment of aortic stenosis severity.
Variation in echocardiography machines and probes are not well described in the perioperative period. We aimed to compare the estimation of severity of aortic stenosis with transthoracic echocardiography (TTE) using two semi-portable ultrasound machines. Experienced cardiac anaesthetists performed a limited transthoracic echocardiogram with two different semi-portable ultrasound machines in patients with known aortic stenosis. ⋯ However, the velocities obtained by the M Turbo were significantly lower than those obtained by the formal preoperative transthoracic echocardiogram (P <0.001). With the expansion of transthoracic echocardiography amongst anaesthetists, underestimation of the peak aortic jet velocity can significantly underestimate the severity of aortic stenosis with potentially lethal clinical consequences. Semi-portable ultrasound machines with echocardiographic capability are not necessarily equivalent and can result in underestimation of severity of aortic stenosis.
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In early 2015, the Medical Board of Australia commissioned research into international revalidation models and what might be applicable for Australia. This review examines the implications for Australian anaesthetists. ⋯ Although its evidence base is limited, the General Medical Council in the United Kingdom is evaluating its revalidation system, which should provide useful guidance for other countries. Australian anaesthetists and their professional organisations must remain informed about, and engaged in, the national debate about revalidation, to ensure that any new process is workable for Australian anaesthesia practice.