Anaesthesia and intensive care
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Anaesth Intensive Care · Feb 1984
Use of a pharyngeal guide to aid intubation with the fibreoptic laryngoscope.
The fibreoptic laryngoscope is a difficult instrument to master in anaesthetised patients, and reasons for this are discussed. The use of a pharyngeal guide was shown to provide an acceptable success rate in patients without anatomical deformity. These guides may also be beneficial to those with such deformities.
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A knowledge of pharmacokinetic principles is essential to understand dosage modification for drugs used in patients in renal failure. Dosage modification is indicated either where drugs have a low therapeutic index, or where renal mechanisms play a major role in drug elimination. ⋯ In addition to effects on drug elimination, renal failure may also alter drug absorption, distribution, protein binding and metabolism. Dialysis regimens, by eliminating drugs to a greater or lesser degree, have implications for drug therapy.