The Clinical journal of pain
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The complex regional pain syndrome type I (CRPS I) is one of the main complications after a fracture of the distal radius. The underlying pathology is not fully understood. Different theories have been put forward to explain the pathogenesis of this disease, some including genetic models. The aim of this study was to find a possible genetic involvement in the occurrence of CRPS I. ⋯ This study suggests the rs1048101 single nucleotide polymorphism within the alpha1a-adrenoceptor as one risk factor for the development of CRPS I after the distal radius fracture.