The Clinical journal of pain
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Randomized Controlled Trial
Botulinum Toxin A in Postherpetic Neuralgia: A Parallel, Randomized, Double-Blind, Single-Dose, Placebo-controlled Trial.
Cumulative evidence support a beneficial effect of botulinum toxin A (BTX-A) in postherpetic neuralgia (PHN). We aimed to assess efficacy, safety, and tolerability of BTX-A in the management of PHN, performing a randomized, double-blind, single-dose, placebo-controlled trial. ⋯ Data confirm that BTX-A is effective and well tolerated in the treatment of PHN.
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Controlled Clinical Trial
Suppression of Emotion Expression Mediates the Effects of Negative Affect on Pain Catastrophizing: A Cross-Sectional Analysis.
Negative affect is associated with individual differences in pain catastrophizing (PC). Research suggests that variations in emotion regulation may modify negative affect on PC. Using the process model of emotion regulation, this study examined the relationships of 2 emotion regulatory strategies, cognitive reappraisal and expressive suppression, with negative affect and PC. ⋯ These preliminary findings suggest that expressive suppression of emotion plays a mediating role in PC and subsequent pain adjustment outcomes. More research is needed to further examine other types of negative emotions and different emotion regulatory strategies used in chronic pain adjustment.
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Comparative Study
Hypogonadism in Men With Chronic Pain Linked to the Use of Long-acting Rather Than Short-acting Opioids.
There is a need to elucidate the variables associated with testosterone suppression among men on daily opioid therapy for chronic pain. ⋯ Among a contemporary sample of men receiving chronic daily opioids, we found a high prevalence of hypogonadism associated with duration of action, but not with total daily dose of the opioid.
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To investigate the relation between localized pressure pain sensitivity and the amplitude and specificity of semispinalis cervicis muscle activity in patients with chronic neck pain. ⋯ In contrast to asymptomatic individuals, the semispinalis cervicis muscle displays reduced and less-defined EMG activity during a multidirectional isometric contraction in patients with chronic neck pain. The altered behavior of the semispinalis cervicis is weakly associated to pressure pain sensitivity.