The Canadian journal of cardiology
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Review Comparative Study
The efficacy and safety of combination warfarin and ASA therapy: a systematic review of the literature and update of guidelines.
The English-language literature was systematically reviewed to clarify the role of combination antithrombotic therapy with warfarin and acetylsalicylic acid (ASA) versus monotherapy with either agent, including data from several recently published trials. Sixteen published studies with evaluable efficacy and/or safety data were identified. For patients with prosthetic heart valves at high risk of thromboembolism, combined warfarin and ASA therapy may be beneficial compared with warfarin alone. ⋯ Evidence does not support the use of combined antithrombotic therapy in patients with established ischemic heart disease, ischemic stroke, coronary artery bypass grafts or atrial fibrillation. Combination therapy is associated with an increased risk of minor and major bleeding. The highest dose of ASA that can be recommended in combination with warfarin is 100 mg daily.
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Comparative Study
Postoperative laboratory and imaging investigations in intensive care units following coronary artery bypass grafting: a comparison of two Canadian hospitals.
To compare the utilization and cost of common laboratory and imaging tests following admission to the intensive care unit (ICU) after coronary artery bypass surgery in two hospitals. The hospitals use different strategies to order tests postoperatively: one hospital uses a mandated protocol while the other does not. ⋯ There are marked differences in the investigation pattern and costs for coronary artery bypass patients admitted to ICU in these hospitals. It is suggested that the benefits of frequent routine determinations of bloodwork, electrocardiograms and chest radiographs should be reevaluated in this patient population.
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To determine how people in a moderately sized Ontario city believe they will react if they witness someone colapsing. ⋯ Older people do not know how to act effectively in a cardiac emergency. Traditional CPR and public awareness programs have been ineffective in reaching this population; alternative means are required to help the public respond more effectively to cardiac emergencies.
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This article proposes a modification of a hospital cardiopulmonary resuscitation (CPR)/do not resuscitate (DNR) policy that prescribes CPR for all unless a DNR order is agreed to by patient and physician. Rather than maintaining CPR as an intervention that can be avoided only by a negative order, the proposed modified policy supports a positive order, i.e., perform CPR when beneficial unless the patient refuses. To provide a clinical basis for an ethical discussion comparing the current policy with the modified proposal, a brief review of the outcome of CPR in terms of survival to discharge is presented. ⋯ The modified proposal should provide a more realistic framework within which to evaluate the needs and wishes of patients at this difficult and emotional time. This concept is implemented by establishing the CPR status of all patients as one component of their positive treatment regimen, rather than having CPR as an intervention to be avoided only by the DNR order. The author discusses the current and proposed policy relative to their effect on patient selection, discussion with patients about CPR, the dilemma that results when the patient insists on CPR when it is not recommended and the protection of patient autonomy.