International journal of oral and maxillofacial surgery
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Int J Oral Maxillofac Surg · Apr 2009
Randomized Controlled TrialA randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model.
Assessment of postoperative sequelae following the removal of an impacted third molar has been used in clinical pharmacology to evaluate the relative efficacy of various analgesic, anti-inflammatory drugs. This study included 150 patients with impacted lower third molars. They were randomly sorted to receive ibuprofen, paracetamol, betamethasone, serratiopeptidase or placebo. ⋯ A significant rise in temperature on the operated side occurred only on day 1 in all the groups. Serratiopeptidase did not showed significant analgesic and anti-inflammatory action. Mild-to-moderate adverse effects were reported.
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Int J Oral Maxillofac Surg · Feb 2009
ReviewA systematic review of the role of immunonutrition in patients undergoing surgery for head and neck cancer.
Patients with head and neck cancer are often malnourished and have a high incidence of postoperative complications. Studies of patients with head and neck cancer receiving immunonutrition in the perioperative period have suggested, but not conclusively demonstrated, benefit. This study reviews randomised trials comparing perioperative standard polymeric nutrition or no nutritional supplementation with immunonutrition in the treatment of head and neck cancer. ⋯ Perioperative immunonutrition is associated with reduced length of hospital stay; the mechanism is unclear as other outcomes were not improved. Trials were small with incomplete reporting of outcomes. An adequately powered trial is required to substantiate benefit.
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Int J Oral Maxillofac Surg · Oct 2008
Bone regeneration of critical calvarial defect in goat model by PLGA/TCP/rhBMP-2 scaffolds prepared by low-temperature rapid-prototyping technology.
Active artificial bone composed of poly lactide-co-glycolide (PLGA)/ tricalcium phosphate (TCP) was prefabricated using low-temperature rapid-prototyping technology so that the process of osteogenesis could be observed in it. PLGA and TCP were the primary materials, they were molded at low temperature, then recombinant human bone morphogenetic protein-2 (rhBMP-2) was added to form an active artificial bone. Goats with standard cranial defects were randomly divided into experimental (implants with rhBMP-2 added) and control (implants without rhBMP-2) groups, and osteogenesis was observed and evaluated by imaging and biomechanical and histological examinations. ⋯ The three-point bending strength of the repaired defects attained that of the normal cranium. In conclusion, low-temperature rapid-prototyping technology can preserve the biological activity of this scaffold material. The scaffold has a good three-dimensional structure and it becomes an active artificial bone after loading with rhBMP-2 with a modest degradation rate and excellent osteogenesis in the goat.
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Int J Oral Maxillofac Surg · Oct 2008
Comparative StudyShort-term recovery after orthognathic surgery: a medical daily diary approach.
This study assessed the utility of a quality-of-life diary for the assessment of postoperative recovery following orthognathic surgery. A 20-item daily recovery diary was designed to assess the patients' perception of recovery in 4 domains (postoperative sequelae; pain/discomfort; oral function; daily activities) during each of the first 90 days after surgery. Fifteen of 185 patients who had agreed to participate did not return any portion of the diary. ⋯ At 30 days, a lower percentage, in general, of patients who completed all 90 days reported recovery in oral function and general activity compared with those who did not complete all diary days. This study confirms that patients will cooperate with the completion of structured medical / health-related quality-of-life diaries during the first few months after orthognathic surgery. Information from such diaries would be valuable to patients deciding on treatment options and to the clinicians counseling them.
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Int J Oral Maxillofac Surg · Sep 2008
Randomized Controlled Trial Comparative StudyEffect of ice compression on pain after mandibular third molar surgery: a single-blind, randomized controlled trial.
This study was designed to investigate the effect of compression with ice and compression alone on pain and quality of life after surgical removal of mandibular third molars. A prospective, single-blind, randomized controlled study design was chosen. Participants in group A applied 45 min of repeated compression with ice; those in group B applied 45 min of repeated compression without ice (control); and those in group C did not apply any compression. ⋯ Based on the GPE ratings, in groups A and B more patients indicated that pain was reduced successfully, but this was not statistically significant. Quality of life was significantly better for patients in groups A and B. These results demonstrate that compression after surgical removal of mandibular third molars is a valuable method for preventing pain.