Journal of general internal medicine
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Randomized Controlled Trial
Valdecoxib for treatment of primary dysmenorrhea. A randomized, double-blind comparison with placebo and naproxen.
To compare the analgesic efficacy of valdecoxib with placebo and naproxen sodium for relieving menstrual cramping and pain due to primary dysmenorrhea. ⋯ Valdecoxib provided a fast onset of analgesic action, a level of efficacy similar to naproxen sodium, and a high level of patient satisfaction in the relief of menstrual pain due to primary dysmenorrhea. Valdecoxib was effective and well tolerated and thus appears to be a viable treatment for menstrual pain due to primary dysmenorrhea.
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To evaluate the effect of alcohol on coronary heart disease (CHD), cancer incidence, and cancer mortality by smoking history. ⋯ Health behavior counseling regarding alcohol consumption for cardioprotection should include a discussion of the lack of a decreased risk of CHD mortality for current smokers and the increased cancer risk among former and current smokers.
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Both clinical trials and observational studies of persons with HIV infection commonly include health-related quality of life (HRQOL) measures, but less is known about the relation of HRQOL to survival among persons with HIV since the development of effective antiretroviral treatment. ⋯ Physical HRQOL added prognostic information over and above the sociodemographic and routinely available clinical data such as CD4 count and stage of HIV infection. Measurement of HRQOL, which is often performed to identify problems or assess outcomes, is also useful prognostically.