Journal of general internal medicine
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In 1960, Dr. William Dock, visiting professor at Yale, discussed the case of a young girl with an unknown liver disease. Dock recommended biopsy, invoking bank robber Willie Sutton's words "that's where the money is." Drs. ⋯ Without them, and the unknown medical student who made the diagnosis of schistosomiasis, there would be no Sutton's Law. For many, it is an obsolete and apocryphal aphorism valuable solely for touting the importance of specificity in tissue diagnosis. For others, it has evolved, remaining relevant as an authentic lesson in decision-analysis, past and present.
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Direct-acting oral anticoagulants (DOACs) are recommended to reduce risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation (NVAF). However, DOAC dosing inconsistent with FDA-approved product labels is common and associated with poor clinical outcomes. ⋯ DOAC dosing inconsistent with label varied by demographics, clinical characteristics, prescriber specialty, and healthcare system, suggesting a need to monitor and assess dosing decisions in NVAF. Identification of variables associated with dosing inconsistencies may enable targeted interventions to ensure label-consistent dosing in vulnerable populations.