Journal of pain and symptom management
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J Pain Symptom Manage · Mar 2018
ReviewMethadone as first line opioid in cancer pain management: a systematic review.
The objective of this review was to assess the existent evidence for the use of methadone as a first-line therapy in cancer pain management. ⋯ Available data are not sufficient to draw net conclusion. However, open-label and controlled studies have shown that methadone may be effective as first-line drug in the management of cancer pain, providing analgesia and adverse effect profiles similar to those produced by other opioids. The finding that methadone doses tend to remain stable suggests that metabolic characteristics and extraopioid analgesic effects, as its well antihyperalgesic properties may be interesting potential advantages. Further studies should provide information regarding the long-term use of methadone or the need to switch from methadone to other opioids when a loss of analgesic response occurs.
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J Pain Symptom Manage · Mar 2018
Comparative StudyA Comparison of the Accuracy of Clinician Prediction of Survival Versus the Palliative Prognostic Index.
Survival predictions for advanced cancer patients impact many aspects of care, but the accuracy of clinician prediction of survival (CPS) is low. Prognostic tools such as the Palliative Prognostic Index (PPI) have been proposed to improve accuracy of predictions. However, it is not known if PPI is better than CPS at discriminating survival. ⋯ We found that PPI was more accurate than CPS when used to discriminate survival at 30 days, but not at 100 days. This study highlights the reason and timing for using PPI to facilitate survival predictions.
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J Pain Symptom Manage · Mar 2018
Randomized Controlled TrialEffects of Tai Chi Exercise on Cancer-Related Fatigue in Patients with Nasopharyngeal Carcinoma Undergoing Chemoradiotherapy: A Randomized Controlled Trial.
Tai Chi exercise has been shown to improve cancer-related fatigue (CRF) and autonomic nervous system (ANS) balance in some cancer patients or survivors; however, such effects are yet to be verified in nasopharyngeal carcinoma (NPC) patients undergoing chemoradiotherapy. ⋯ Tai Chi exercise is conducive to alleviate CRF in NPC patients undergoing chemoradiotherapy. The improvement in ANS balance might fit into the process of Tai Chi for CRF management in this population.
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J Pain Symptom Manage · Mar 2018
Minimal Clinically Important Difference of the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF) for Fatigue Worsening in Asian Breast Cancer Patients.
The minimal clinically important difference (MCID) of the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF), a questionnaire that measures cancer-related fatigue, has not been established in patients with cancer. ⋯ The MCID of the MFSI-SF identified by all approaches ranged from 4.50 to 10.79 points. The MCID can be used to interpret the clinical significance of fatigue deterioration in patients with breast cancer and to determine sample sizes for future clinical trials.
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J Pain Symptom Manage · Mar 2018
Changes in the occurrence, severity, and distress of symptoms in patients with gastrointestinal cancers receiving chemotherapy.
Studies on multiple dimensions of the symptom experience of patients with gastrointestinal cancers are extremely limited. ⋯ Demographic and clinical characteristics associated with differences in enrollment levels as well as changes over time in occurrence, severity, and distress of these seven common symptoms were highly variable. These findings can be used to identify patients who are at higher risk for more severe and distressing symptoms during CTX and to enable the initiation of preemptive symptom management interventions.