Current medical research and opinion
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The aim of this study was to quantify the effect of non-persistence with oral glucose-lowering drugs (OGLD) on HbA(1c) goal attainment (<7%) in daily practice. ⋯ Non-persistent use of OGLD leads to a 20% decreased probability of HbA(1c) goal attainment in daily practice. This effect of non-persistence seems modest, but represents around 12 000 new and 10 000 prevalent OGLD users a year in the Netherlands in whom OGLD use could be better controlled.
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Randomized Controlled Trial
Efficacy and safety of exenatide administered before the two largest daily meals of Latin American patients with type 2 diabetes.
To evaluate whether exenatide administered before breakfast and dinner (BD) or before lunch and dinner (LD) provided similar glycemic control in Latin American patients with type 2 diabetes mellitus (T2DM) who consume a small breakfast. ⋯ In T2DM patients who consume a small breakfast, exenatide administration before breakfast or lunch resulted in significant improvement in glycemic control.
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Comparative Study
Comparison of escitalopram versus citalopram for the treatment of major depressive disorder in a geriatric population.
To compare escitalopram versus citalopram for the treatment of major depressive disorder (MDD) in geriatric patients. ⋯ Geriatric patients treated with escitalopram had better treatment persistence, fewer hospitalizations, and lower medical and total healthcare costs than patients treated with citalopram. Most of the cost reduction was attributable to significantly lower hospitalizations and total medical costs.