Current medical research and opinion
-
Multicenter Study Comparative Study Clinical Trial
Comparative risk of microalbuminuria and proteinuria in UK residents of south Asian and white European ethnic background with type 2 diabetes: a report from UKADS.
This study investigated and compared the prevalence of microalbuminuria and overt proteinuria and their determinants in a cohort of UK resident patients of white European or south Asian ethnicity with type 2 diabetes mellitus. ⋯ A total of 1978 patients, comprising 1486 of south Asian and 492 of white European ethnicity, in 25 general practices in Coventry and Birmingham inner city areas in England were studied in a cross-sectional study. Demographic and risk factor data were collected and presence of microalbuminuria and overt proteinuria assessed.
-
Randomized Controlled Trial
Oral corticosteroid sparing with omalizumab in severe allergic (IgE-mediated) asthma patients.
Long-term oral corticosteroid (OCS) therapy and related adverse events are associated with a significant burden on patients and healthcare resources. ⋯ In this open-label study of patients with severe allergic asthma, OMA/OAT therapy reduced maintenance OCS use, compared with OAT alone. Improvements in efficacy measures were observed in the OMA/OAT group, irrespective of OCS change. CLINICALTRIALS.GOV IDENTIFIER: NCT00264849.
-
To assess the impact of intraoperative dexmedetomidine infusion on postoperative analgesia in women undergoing major open and laparoscopic gynecologic surgery under general anesthesia. ⋯ Intraoperative dexmedetomidine infusion provided an opioid sparing effect intraoperatively and in PACU in women undergoing open gynecologic surgery but did not reduce the need for rescue antiemetics or the duration of PACU stay and did not provide any benefit beyond PACU discharge. For laparoscopic surgery, dexmedetomidine infusion did not provide any analgesic benefit. Limitations of the study include its retrospective non-randomized nature, absence of strict protocol for dexmedetomidine administration and lack of data beyond PACU discharge in patients having laparoscopic surgery.
-
To study patient preferences for diabetes-treatment related attributes among people with type 2 diabetes. ⋯ Patients with type 2 diabetes in Denmark were willing to pay for the health benefits associated with improved diabetes treatment, the most important of these being weight loss or avoidance of weight gain, and reduction of HbA(1c) and of hypoglycaemic events.