Current medical research and opinion
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Lactose intolerance (LI) is the failure to digest foods and beverages containing the lactose present in milk. LI can present by many digestive symptoms. ⋯ Modified CoMiSS is a simple, fast, and easy-to-use tool that can predict LI, with a cut-off value of >8, the Area under the ROC Curve was 0.998, sensitivity 89.5%, and specificity was 100%.
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Publication-associated plain language summaries are brief, jargon-free summaries of scientific publications. They are intended for a broad, non-expert audience to help maximize the accessibility of the publication. Plain language summaries are typically found alongside peer-reviewed publications or in supplementary materials and can be indexed in PubMed. In this narrative commentary, we present the perspectives of five day-to-day users of plain language summaries from different stakeholder groups, gained through semi-structured qualitative interviews about the users' experiences with and opinions of plain language summaries.
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At global level, the pandemic coronavirus disease 2019 (COVID-19) is known to be caused by an etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Numerous evidence and propositions have emerged on the molecular and cellular attributes that cause COVID-19. ⋯ In this direction, preclinical and clinical data on the comorbidities in the case of mitochondrial defective disease and COVID-19 are not available. The authors propose that patients harboring primary mitochondrial disease and secondary mitochondrial dysfunction will display a higher severity and death rate compared to healthy mitochondria harboring patients.
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This study aimed to develop and validate a predictive algorithm for unsatisfactory response to initial pulmonary arterial hypertension (PAH) therapy using health insurance claims. ⋯ The present claims-based algorithm performed well in predicting time to unsatisfactory response following initial PAH therapy.