Current medical research and opinion
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The prevalence of hypothyroidism in systemic lupus erythematosus (SLE) is significantly higher than that in the common public. While SLE itself can affect multiple organs, abnormal thyroid function may exacerbate organ damage in patients with SLE. We aimed to predict abnormal thyroid function and to examine the associated factors with multiple machine learning approaches. ⋯ Random Forest model performed best and is recommended for selecting vital indices and assessing clinical complications of SLE, it indicated that anti-SSB and anti-dsDNA antibodies may play principal roles in the development of hypothyroidism in SLE patients. It's feasible to build an accurate machine learning model for early diagnosis or risk factors assessment in SLE using clinical parameters, which would provide a reference for the research work of SLE in China.
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As cerebral mucormycosis is devastating in nature, here we discuss possible use of the intranasal route, in comparison to or in addition to intravenous administration, as a therapeutic approach to manage cases of mucormycosis with central nervous system involvement.
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Most human diseases are accompanied by systems changes. Systems biomarkers should reflect such changes. The phosphorylation and dephosphorylation of biomolecules maintain human homeostasis. However, the systems biomarker characteristics of circulating alkaline phosphatase, a routine blood test conducted for many human diseases, have never been investigated. ⋯ Alkaline phosphatase was a decent systems biomarker for 19 different types of human diseases. Understanding the molecular mechanisms of over-up-and-down-regulation of ALP activities might be the key to understanding the whole-body systems' reactions during specific disease progression.