Current medical research and opinion
-
This paper investigates the relationship between the positivity rate and numbers of deaths and intensive care unit (ICU) patients. In addition, it explores the use of the positivity rate as an indicator for the spread of COVID-19. ⋯ The results indicate that positivity rate is a better indicator for the spread of the disease than the number of confirmed cases. Therefore, it is highly advised to use measures based on the positivity rate when indicating the spread of the disease and considering responses accordingly because these measures consider the daily number of tests and confirmed cases.
-
Observational Study
Cross-cultural adaptation and validation of the Persian version of the painDETECT questionnaire.
The purpose of this study was to translate and cross-culturally adapt the painDETECT questionnaire into the Persian language and assess the clinometric properties of the translated version (P-PDQ). ⋯ The P-PDQ is a reliable and valid tool to distinguish neuropathic component in chronic pain cases.
-
Acute myeloid leukemia (AML) is a highly malignant blood cancer disease, with dismal prognosis. The theory that cancer cells utilize metabolism to their growth advantage was postulated almost hundred years ago. ⋯ Current observations suggest a crucial role for various metabolic pathways in AML, and special in leukemia stem cells, believed to be responsible for re-initiation of the leukemic clone, and hence relapse of this devastating disease. In the present article we discuss the features for metabolism in AML based on recent research, and special emphasizing the potential of pharmacological inhibiting metabolism as new treatment approaches.
-
Observational Study
Isoflurane not at the expense of postoperative nausea and vomiting in cardiac anesthesia - an observational study.
Inhalative anesthesia is of common use, but is generally known to potentiate postoperative nausea and vomiting (PONV). With an internal change of anesthesia regimen from total intravenous anesthesia (TIVA) to isoflurane (in terms of myocardial protection) in cardiac anesthesia a higher incidence of PONV was to be expected. Therefore, we evaluated the incidence of PONV after the simultaneous implementation of PONV prophylaxis. ⋯ In cardiac anesthesia, the use of isoflurane is not at the expense of PONV when using a risk-independent two-drug-prophylaxis. It is even beneficial resulting surprisingly in a lower incidence of PONV than under TIVA unless with and without prophylaxis. Patients with the highest risk for PONV and receiving isoflurane should receive a third antiemetic prophylactic drug.