Revista clínica española
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Revista clínica española · Oct 2008
Review[New CCR5 inhibitor antiretroviral drugs and integrase inhibitors].
Two new antiretroviral drugs belonging to a new drug family have recently been marketed in Spain. These are maraviroc (CCR5 correceptor inhibitor) and raltegravir (integrase inhibitor). These have the advantage of not presenting crossed resistance with other previously administered antiretroviral drugs, converting them into the cornerstone of the rescue treatment in the patient infected by a multiresistant viral strain. The scientific evidence available on these two drugs is reviewed in this work and its indications in the HIV infected patient are discussed.
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Revista clínica española · Oct 2008
Review[Introducing formative portfolio as a tool for Internal Medicine residents mentoring: review of a pilot project, 2005-2006].
Recent educational projects in our country have been trying to introduce professional portfolios as assessment/learning tools on the undergraduate and specialized post-graduate education levels. The approval of a new formative program for the Internal Medicine specialty in an effort to adapt to the present health care needs offers an opportunity to apply these formative and evaluative methodologies in the learning process of future internists. ⋯ This article describes the project of designing, developing, applying and assessing an electronic portfolio for first year Internal Medicine residents. It presents an analysis of the SEMI Portfolio strengths and weaknesses and finally makes suggestions for future development.
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Revista clínica española · Oct 2008
Multicenter Study[Seroprevalence of chronic viral hepatitis markers in 791 recent immigrants in Catalonia, Spain. Screening and vaccination against hepatitis B recommendations].
The prevalence of chronic viral hepatitis in the European Union (EU) will vary because of the immigrants coming from countries having an elevated with a higher endemicity of hepatitis B (HBV) and C virus (HCV). Serologic screening in healthy immigrants is a subject that has been discussed in the areas of feasibility, ethics and cost-effectiveness. The main study aims were: a) to know the prevalence of chronic hepatitis markers and, b) to determine the best cost-effectiveness strategy of vaccination against hepatitis B. ⋯ The prevalence of chronic viral hepatitis markers is found to be at an intermediate level between those described by primary and specialized care levels. The prevalences of HBsAg+ and anti-HC+ in the immigrant population, on the whole, are such that it is advisable to screening for them, with the exception of the Latin American community. Previous serologic determination of markers is only cost-effective among the sub-Saharan community.