Journal of dental research
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Randomized Controlled Trial Comparative Study Retracted Publication
A clinical trial of pulpotomy vs. root canal therapy of mature molars.
Root canal therapy (RCT) and tooth extraction are the main treatment options for irreversible pulpitis or its sequelae. Pulpotomy is an alternative treatment; however, more evidence is required. If outcomes of pulpotomy with a calcium-enriched mixture (PCEM) are non-inferior for mature molars with irreversible pulpitis compared with those from one-visit RCT (ORCT), this may be a beneficial treatment option. ⋯ Clinical success rates in the two arms showed no statistically significant difference; however, the radiographic success rates were significantly greater in the PCEM arm (P < 0.001). This trial suggests PCEM as an alternative for treatment of irreversible pulpitis. If long-term results confirm initial ones, PCEM may revolutionize oral health worldwide.
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Craniofacial pain, whether odontogenic or caused by cardiac ischemia, is commonly referred to the same locations, posing a diagnostic challenge. We hypothesized that the validity of pain characteristics would be high in assessment of differential diagnosis. Pain quality, intensity, and gender characteristics were assessed for referred craniofacial pain from dental (n = 359) vs. cardiac (n = 115) origin. ⋯ No gender differences were found. These data should now be added to those craniofacial pain characteristics already known to point to acute cardiac disease rather than dental pathology, i.e., pain provocation/aggravation by physical activity, pain relief at rest, and bilateralism. To initiate prompt and appropriate treatment, dental and medical clinicians as well as the public should be alert to those clinical characteristics of craniofacial pain of cardiac origin.
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The effects of prolonged tooth-clenching on masticatory muscle pain have not been fully elucidated. We hypothesized that late-onset soreness may develop depending on the clenching force. Ten pain-free females were asked to endure sustained clenching tasks up to exhaustion in randomized sequences of 7.5%, 10%, 15%, 25%, and 40% of maximum clenching force. ⋯ Masseter pressure-pain threshold decreased immediately after (-13.7%; p = 0.050) and one day after (-22.0%; p = 0.006) the 7.5% task. Temporalis pressure threshold decreased one day after the 7.5 % task (-14.6%; p = 0.003). It was concluded that prolonged low-level tooth-clenching in healthy young women induces a delayed soreness in the jaw elevator muscles.
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Hypoxia is an integral component of the inflamed tissue microenvironment. Today, the influence of hypoxia on the natural evolution of inflammatory responses is widely accepted; however, many molecular and cellular mechanisms mediating this relationship remain to be clarified. ⋯ This review summarizes the current knowledge on hypoxia-responsive transcriptional pathways in inflammation and their importance in the etiology of chronic inflammatory diseases, with the primary focus on transcriptional co-regulators and histone modifications in defining gene-specific transcriptional responses in hypoxia, and on the recent progress in the understanding of hypoxia-mediated epigenetic reprogramming. Furthermore, this review discusses the molecular cross-talk between glucocorticoid anti-inflammatory pathways and hypoxia.