Journal of critical care
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Journal of critical care · Mar 1995
Comparative StudyThe role of platelet-activating factor in lipopolysaccharide-induced myocardial depression in guinea pigs.
To determine if platelet-activating factor (PAF) is a key mediator of lipopolysaccharide (LPS)-induced myocardial depression in guinea pigs. ⋯ PAF does not appear to be a primary mediator of LPS-induced myocardial depression in guinea pigs. LPS may impair SR calcium release thereby causing cardiac dysfunction.