Journal of critical care
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Journal of critical care · Jun 1995
Comparative StudyNeuromuscular blockade provides no benefit over adequate sedation in ventilated dogs.
To investigate the effect of pharmacological paralysis on systemic oxygen consumption to determine whether pharmacological paralysis offers a physiological benefit over adequate sedation in ventilated animals. ⋯ Pharmacological paralysis of mechanically ventilated animals with normal pulmonary function that are sedated and resting comfortably produces a statistically significant reduction in oxygen consumption; however, the magnitude of this change is so small that little genuine clinical benefit would be anticipated.