Journal of critical care
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Journal of critical care · Apr 2015
Meta AnalysisAdjuvant treatment with crude rhubarb for patients with systemic inflammation reaction syndrome/sepsis: A meta-analysis of randomized controlled trials.
The objective of this study is to evaluate the benefits of adjuvant treatment with crude rhubarb in patients with systemic inflammation reaction syndrome/sepsis by conducting a meta-analysis. ⋯ Adjuvant treatment with crude rhubarb appears to have additional benefits in septic patients. Antiinflammation and anticoagulant/antiaggregant properties may be its potential mechanism.
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Journal of critical care · Apr 2015
Observational StudyChanges in fibrinolysis and severity of organ failure in sepsis: A prospective observational study using point-of-care test-ROTEM.
We hypothesized that the thromboelastometry (ROTEM; Pentapharm GmbH, Munich, Germany) fibrinolysis parameter "maximum lysis" (ML) would have an independent inverse association with the severity of organ failure in sepsis. ⋯ Lower ML and higher INR values predicted greater severity of organ failure at presentation. Further studies are required, as ROTEM could aid selection of patients and guide interventions aimed at fibrinolysis in severe sepsis.
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Journal of critical care · Apr 2015
Correlation of lactate/albumin ratio level to organ failure and mortality in severe sepsis and septic shock.
This study examines the clinical utility of the increased lactate/albumin ratio as an indicator of multiple-organ dysfunction syndrome (MODS) and mortality in severe sepsis and septic shock. ⋯ Increased lactate/albumin ratio correlates with the development of MODS and mortality in patients with severe sepsis and septic shock.
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Journal of critical care · Apr 2015
Clinician perspectives on protocols designed to minimize sedation.
Within a multicenter randomized trial comparing protocolized sedation with protocolized sedation plus daily interruption (DI), we sought perspectives of intensive care unit (ICU) clinicians regarding each strategy. ⋯ Most respondents liked both sedation strategies. Nurses and physicians had different preferences and rationales for liking or disliking each strategy.